{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:37:26Z","timestamp":1791596246054,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["656665740365, CT 648\u20102014"],"award-info":[{"award-number":["656665740365, CT 648\u20102014"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic Chagas cardiomyopathy (CCM) is characterized by a unique type of cardiac involvement. Few studies have characterized echocardiographic (Echo) transitions from the indeterminate Chagas disease (ChD) form to CCM. The objective of this study was to identify the best cutoffs in multiple Echo parameters, speckle tracking, and N\u2010terminal pro B\u2010type natriuretic peptide (NT\u2010proBNP) to distinguish patients without CCM (stage A) vs patients with myocardial involvement (stages B, C, or D).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study conducted in 273 consecutive patients with different CCM stages. Echo parameters, NT\u2010proBNP, and other clinical variables were measured. Logistic regression models (dichotomized in stage A versus B, C, and D) adjusted for age, sex, body mass index, and NT\u2010proBNP were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Left ventricular global longitudinal strain (LV\u2010GLS), mitral flow E velocity, LV mass index, and NT\u2010proBNP identified early changes that differentiated stages A vs B, C, and D. The LV\u2010GLS with a cutoff \u221220.5% showed the highest performance (AUC 92.99%; accuracy 84.56% and negative predictive value (NPV) 88.82%), which improved when it was additionally adjusted by NT\u2010proBNP with a cutoff \u221220.0% (AUC 94.30%; accuracy 88.42% and NPV 93.55%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that Echo parameters and NT\u2010proBNP may be used as diagnostic variables in detecting the onset of myocardial alterations in patients with the indeterminate stage of ChD. LV\u2010GLS was the more accurate measurement regarding stage A differentiation from the stages B, C, and D. Prospective longitudinal studies are needed to validate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14603","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T16:20:40Z","timestamp":1581438040000},"page":"429-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Echocardiographic parameters, speckle tracking, and brain natriuretic peptide levels as indicators of progression of indeterminate stage to Chagas cardiomyopathy"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-3859","authenticated-orcid":false,"given":"Luis E.","family":"Echeverr\u00eda","sequence":"first","affiliation":[{"name":"Heart Failure and Transplant Clinic Cardiovascular Foundation of Colombia Floridablanca Colombia"},{"name":"Public Health and Epidemiological Studies Group Cardiovascular Foundation of Colombia Floridablanca 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Colombia Floridablanca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1396-5042","authenticated-orcid":false,"given":"Sergio Alejandro","family":"G\u00f3mez\u2010Ochoa","sequence":"additional","affiliation":[{"name":"Public Health and Epidemiological Studies Group Cardiovascular Foundation of Colombia Floridablanca Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Morillo","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences Libin Cardiovascular Institute of Alberta University of Calgary Calgary AB Canada"},{"name":"Department of Medicine Cardiology Division McMaster University PHRI\u2010HHSC Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar L.","family":"Rueda\u2010Ochoa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Center Rotterdam Rotterdam The 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