{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:18:28Z","timestamp":1791649108187,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T00:00:00Z","timestamp":1585785600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Stress echocardiography (SE) with state\u2010of\u2010the\u2010art imaging protocol allows a comprehensive assessment of regional wall\u2010motion abnormalities and Doppler\u2010based coronary flow velocity reserve (CFVR) in left anterior descending artery (LAD). We sought to assess the variables potentially impacting on success rate of SE with CFVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In a single\u2010center, prospective, observational study design, from 2007 to 2019, we enrolled 2989 consecutive patients (age 67\u00a0\u00b1\u00a012\u00a0years; 1723 men) referred for SE, without contrast, for chronic known (n\u00a0=\u00a01130) or suspected (n\u00a0=\u00a01859) coronary syndromes. Coronary flow velocity reserve was measured as stress\/rest peak diastolic flow velocity. The same operator (LC) performed all examinations with the same machine (GE Vivid 7). Interpretable CFVR was obtained in 2808 patients (feasibility\u00a0=\u00a093.9%). Overall success rate was lowest (91.4%) in 2007\u20132008 and steadily rose to 97.8% in 2017\u20132019 (<jats:italic>P<\/jats:italic> for trend &lt;.0001). Feasibility was excellent for men (93.7%) and women (94.3%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.47) across all values of body mass index (BMI): &lt;25 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.09), 25\u201329 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.84), and \u226530 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.23). At multivariable logistic regression analysis, women with BMI\u00a0\u2265\u00a030 (OR 1.94, 95% CI 1.14\u20133.29, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), resting heart rate \u226577\u00a0beats\/min (OR 2.25, 95% CI 1.64\u20133.11; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), and stress\u2010induced ischemia in the LAD territory (OR 3.14, 95% CI 1.67\u20135.90; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) predicted unfeasible CFVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vasodilator SE with CFVR combined with wall\u2010motion analysis is highly feasible also without contrast although with a slight decline in presence of high resting heart rate (reducing diastolic time essential for flow imaging), women with BMI\u00a0\u2265\u00a030 (increasing tissue thickness interposed between transducer and artery), and anterior ischemia (for underlying low\u2010absent anterograde flow for severely stenotic or occluded LAD).<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14632","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T18:56:16Z","timestamp":1585853776000},"page":"520-527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical, hemodynamic, and functional variables affecting success rate of coronary flow velocity reserve detection during vasodilator stress echocardiography"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1804-4939","authenticated-orcid":false,"given":"Lauro","family":"Cortigiani","sequence":"first","affiliation":[{"name":"Cardiology Division San Luca Hospital Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bovenzi","sequence":"additional","affiliation":[{"name":"Cardiology Division San Luca Hospital Lucca Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6375-6361","authenticated-orcid":false,"given":"Eugenio","family":"Picano","sequence":"additional","affiliation":[{"name":"CNR Institute of Clinical Physiology Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,2]]},"reference":[{"issue":"12","key":"e_1_2_7_2_1","first-page":"2280","article-title":"Podcast. 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