{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T17:08:49Z","timestamp":1756573729487,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dilatation of the ascending aorta has an important role in the anatomical conformation of interatrial septum (IAS) especially when a patent foramen ovale (PFO) is present. The aim of the study was to investigate the relationship between ascending aortic dilation and PFO\u2010related cryptogenic stroke in a cohort of cryptogenic strokes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>It is a retrospective, single\u2010center echocardiographic study assessing aortic root dilatation in 315 consecutive patients with cryptogenic stroke between January 2011 and January 2019. Aortic root dilatation was defined by a diameter of the Valsalva sinuses of the proximal aorta &gt;40\u00a0mm. Predictive factors of PFO were assessed by a multivariate analysis. Propensity score matching was applied to account for clinical differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 315 patients, 68 (22%) had an aortic root dilatation and 167 (53%) had a PFO. In the aortic root dilation group, PFO was more often diagnosed (n\u00a0=\u00a047\/68 [69%], vs n\u00a0=\u00a0120\/247 [49%], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004). In the PFO group with aortic dilatation, IAS was more mobile (n\u00a0=\u00a037\/47[79%] vs n\u00a0=\u00a069\/120[57%], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.012) and smaller (2.3\u00a0\u00b1\u00a00.5 vs 2.5\u00a0\u00b1\u00a00.5\u00a0mm, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.009). On multivariate analysis, aortic root dilatation (OR: 2.6; 95% CI [1.2\u20135.6]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) and IAS hypermobility (OR: 5.2 95% CI [2.7\u201310]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) were associated with PFO. After propensity matching, aortic root dilatation remained strongly associated with PFO (n\u00a0=\u00a034\/107 [32%] vs 15\/107[14%], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Aortic root dilation and IAS hypermobility were strongly associated with PFO\u2010related cryptogenic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14711","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T14:16:53Z","timestamp":1590416213000},"page":"883-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Aortic root dilatation in PFO\u2010related cryptogenic stroke: A propensity score\u2013matched analysis"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8949-7348","authenticated-orcid":false,"given":"Christophe","family":"Beyls","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Amiens University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-9848","authenticated-orcid":false,"given":"Yohann","family":"Bohbot","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amiens University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bourgain","family":"Marion","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amiens University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Canaple","sequence":"additional","affiliation":[{"name":"Department of Neurology Amiens University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Pierre","family":"Guillaumont","sequence":"additional","affiliation":[{"name":"Department of Cardiology Amiens University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Jarry","sequence":"additional","affiliation":[{"name":"Department of Intensive Cardiac Care Unit Amiens University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Intensive Cardiac Care Unit Amiens University Hospital Amiens France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doroth\u00e9e","family":"Malaquin","sequence":"additional","affiliation":[{"name":"Department of Intensive Cardiac Care Unit Amiens University Hospital Amiens 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