{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:45:56Z","timestamp":1778186756849,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of the study was to evaluate the accuracy of the mitral leaflet separation index (MLSI) in selected patients with mitral stenosis, before and after percutaneous balloon mitral valvuloplasty (PBMV), compared to conventional methods with transthoracic echocardiography [TTE].<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted in 30 patients, ages 20\u201060\u00a0years, with severe symptomatic mitral stenosis (MS) who had PBMV in the Cardiology Department, Zagazig University and National Heart Institute. A mean of three to five measurements of MLSI was taken in diastole in the parasternal long\u2010axis and apical four\u2010chamber views. The MLSI was re\u2010measured 24\u201048\u00a0hours after PBMV. We calculated the correlation of the MLSI, pre and post BMV, with two\u2010dimensional (2D) MV planimetry and pressure half\u2010time (PHT) methods to assess MVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a positive, highly significant correlation between pre PBMV 2D planimetry and MLSI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.665, <jats:italic>P<\/jats:italic>\u2010value\u00a0&lt;\u00a0.001) as well as post PBMV 2D planimetry and MLSI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.410, <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0.025). A positive highly significant correlation was also noted between pre PBMV PHT and MLSI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.678, <jats:italic>P<\/jats:italic>\u2010value &lt;.001) and between post PBMV PHT and MLSI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.706, <jats:italic>P<\/jats:italic>\u2010value &lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mitral leaflet separation index is an easy and reliable measurement for the assessment of mitral stenosis before and after PBMV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14754","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T11:47:23Z","timestamp":1595245643000},"page":"1159-1163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mitral leaflet separation index for mitral valve assessment during balloon mitral valvuloplasty"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-8720","authenticated-orcid":false,"given":"Abdulhalim Jamal","family":"Kinsara","sequence":"first","affiliation":[{"name":"Ministry of National Guard\u2010Health Affairs King Abdullah International Medical Research Center King Saud Bin Abdulaziz University for Health Sciences, COM\u2010WR  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-3498","authenticated-orcid":false,"given":"Ahmed Mohammed","family":"Awadallah","sequence":"additional","affiliation":[{"name":"Ministry of National Guard\u2010Health Affairs King Abdullah International Medical Research Center King Saud Bin Abdulaziz University for Health Sciences, COM\u2010WR  Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1916-6671","authenticated-orcid":false,"given":"Manar","family":"AlZaki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-251X","authenticated-orcid":false,"given":"Hala","family":"Goda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9657-5620","authenticated-orcid":false,"given":"Navin","family":"C. Nanda","sequence":"additional","affiliation":[{"name":"Cardiology Division Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"97","article-title":"Has the profile of native infective endocarditis changed over the years?","volume":"12","author":"Drissa M","year":"2020","journal-title":"Arch Cardiovasc Dis Suppl"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43044-019-0019-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3126\/njh.v16i2.26316"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)80023-A"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.02.024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1161\/CIRCULATIONAHA.106.176857","article-title":"ACC\/AHA 2006 guidelines for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (writing committee to revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease): Developed in collaboration with the Society of Cardiovascular Anesthesiologists: endorsed by the Society for Cardiovascular Angiography and Intervention and the Society of Thoracic Surgeons","volume":"114","author":"Bonow RO","year":"2006","journal-title":"Circulation"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001252"},{"issue":"4","key":"e_1_2_8_9_1","first-page":"543","article-title":"Three\u2010dimensional echocardiographic assessment before and after percutaneous transvenous mitral commissurotomy in patients with rheumatic mitral stenosis","volume":"22","author":"Shashanka C","year":"2013","journal-title":"Heart Valve Dis"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2018.04.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8175.2012.01787.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.07.012"},{"key":"e_1_2_8_13_1","first-page":"563","article-title":"Mitral leaflet separation index\u2010A simple novel index to assess the severity of mitral stenosis","volume":"60","author":"Raj BSVF","year":"2008","journal-title":"Indian Heart J"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/768097"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13183"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13805"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.14754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14754","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:12:34Z","timestamp":1693933954000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,20]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/echo.14754"],"URL":"https:\/\/doi.org\/10.1111\/echo.14754","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,20]]},"assertion":[{"value":"2020-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}