{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:01:10Z","timestamp":1747184470763,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Zhenjiang Social Development Foundation","award":["SH2018083"],"award-info":[{"award-number":["SH2018083"]}]},{"name":"social development project of Jiangsu Province","award":["BE2017699","BE2016719"],"award-info":[{"award-number":["BE2017699","BE2016719"]}]},{"name":"Jiangsu medical innovation team project","award":["CXTDA2017010"],"award-info":[{"award-number":["CXTDA2017010"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ischemia\u2010reperfusion injury (IRI) frequently follows successful PCI for STEMI and is recognized by multiple modalities. Multilayer speckle tracking echocardiography (STE) has the potential of detecting myocardial dysfunction in different myocardial layers. Our objective was to describe the changes in layer\u2010specific myocardial function over the 24\u00a0hours after successful PCI for ST\u2010elevation myocardial infarction (STEMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (n\u00a0=\u00a0120) with STEMI and no prior myocardial infarction underwent echocardiography prior to PCI, immediately after and at 3\u2010 and 24\u2010hours post\u2010PCI. Worsening focal dysfunction (WFD) was defined as an immediate reduction, compared to the pre\u2010PCI value, in the amplitude of endo\u2010myocardial longitudinal strain (endo\u2010MLS) within the infarction territory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with WFD (52%) had further reductions in endo\u2010MLS, mid\u2010MLS, and epi\u2010MLS in the infarction region immediately post\u2010PCI; at 3\u00a0hours strain began to improve and continued to improve at 24\u00a0hours. Reductions of endo\u2010MLS strain were more evident than those of global, mid\u2010MLS, and epi\u2010MLS. This same pattern was seen in each of the ischemic territories of the anterior descending, circumflex, and right coronary arteries. Immediate improvement in endo\u2010MLS following PCI was seen in 48% of patients. The time from symptom onset to balloon time was markedly longer in those with WFD (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multilayer SPE is a sensitive method that identifies serial alterations in focal myocardial function following successful PCI for STEMI. Layer\u2010specific reductions in endo\u2010MLS appeared more evident than decreases in global LV strain. Prolonged total ischemic time prior to PCI was directly related to the incidence of WFD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14772","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T22:09:17Z","timestamp":1597097357000},"page":"1413-1421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serial assessment of focal myocardial function after percutaneous coronary intervention for ST\u2010elevation myocardial infarction: Value of layer\u2010specific speckle tracking echocardiography"],"prefix":"10.1111","volume":"37","author":[{"given":"Jing Ping","family":"Sun","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Jiangsu University Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-4981","authenticated-orcid":false,"given":"Fen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangjie","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Bahler","sequence":"additional","affiliation":[{"name":"Case Western Reserve University School of Medicine Cleveland OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-8007","authenticated-orcid":false,"given":"Jinchuan","family":"Yan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University Zhenjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq393"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.12.009"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307855"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.003653"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62001-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.10.015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.04.008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005986"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-018-0474-7"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.020"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.09.007"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.02.003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12901"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.03.052"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.04.010"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.10.004"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14222"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-014-0388-x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.56.5.786"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07120-6"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.04.006"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14106"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.03.021"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fecho.14772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.14772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.14772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T22:00:23Z","timestamp":1693951223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.14772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,10]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/echo.14772"],"URL":"https:\/\/doi.org\/10.1111\/echo.14772","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"type":"print","value":"0742-2822"},{"type":"electronic","value":"1540-8175"}],"subject":[],"published":{"date-parts":[[2020,8,10]]},"assertion":[{"value":"2020-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}