{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:44:08Z","timestamp":1777293848606,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the year 1997, nearly a quarter\u2010century ago, Nishimura and Tajik (<jats:italic>J Am Coll Cardiol<\/jats:italic>. 1997;30:8) suggested that Doppler echocardiography was the \u201cRosetta stone\u201d (a metaphor for decrypting secrets of diastole) of left ventricular diastole, based solely on transmitral E\/A ratio and its progression from grade I through IV, supported by cardiac catheterization, as the filling pressure started to increase to over 15\u00a0mm\u00a0Hg. Ten years later, in 2007, the same Mayo group (Nagueh et al, <jats:italic>J Am Coll Cardiology<\/jats:italic>. 2008;51:679) was searching to decipher the secrets of diastole using multiple measures such as left atrial (LA) volume, E\/E\u02b9 ratio, pulmonary venous flow, and mitral inflow propagation velocity. This substantial leap from E\/A ratio led to the more formal recommendation proposed by the American Society of Echocardiography in 2009 (Nagueh et al, <jats:italic>J Am Soc Echocardiogr<\/jats:italic>. 2009;22:107) and, as an update, in the year 2016 (Nagueh et al, <jats:italic>J Am Soc Echocardiogr<\/jats:italic>. 2016;29:277): the later version gained popularity for the simplified approach to identify diastolic dysfunction in healthy subjects as well as in those with poorly contracting left ventricle. Despite 30\u00a0years of continuous search, we are not sure if we have been able to decipher the hidden secrets of diastolic function. With this background, the <jats:italic>Echocardiography Journal<\/jats:italic> under the leadership of Dr Navin Nanda as the Editor\u2010in\u2010Chief has taken this initiative to publish a theme issue on left ventricular diastolic function and when this becomes dysfunctional to diminish life.<\/jats:p>","DOI":"10.1111\/echo.14830","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T08:10:03Z","timestamp":1606723803000},"page":"1886-1889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Echocardiography 2020: Toward deciphering the \u201cRosetta stone\u201d of left ventricular diastolic function"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-6377","authenticated-orcid":false,"given":"Samir K.","family":"Saha","sequence":"first","affiliation":[{"name":"Umea University Umea Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8336-9430","authenticated-orcid":false,"given":"Anatoli","family":"Kiotsekoglou","sequence":"additional","affiliation":[{"name":"Umea University Umea Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navin C.","family":"Nanda","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00144-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.061"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.023"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.12.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv529"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.09.063"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008291"},{"key":"e_1_2_9_10_1","first-page":"1","article-title":"Diastolic strain time as predictor for systolic dysfunction among patients with active breast cancer","author":"Hochstadt A","year":"2020","journal-title":"Echocardiography"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14498"},{"key":"e_1_2_9_12_1","first-page":"1","article-title":"Diastolic function assessment by echocardiography: a practical manual for clinical use and future applications","volume":"1","author":"Henein MY","year":"2020","journal-title":"Echocardiography"},{"key":"e_1_2_9_13_1","first-page":"1","article-title":"Presence and prognostic value of ventricular diastolic function in arrhythmogenic right ventricular cardiomyopathy","volume":"1","author":"Sadeghpour A","year":"2020","journal-title":"Echocardiography"},{"key":"e_1_2_9_14_1","first-page":"1","article-title":"Left ventricular diastolic function in mitral stenosis","volume":"1","author":"Venkateshvaran A","year":"2020","journal-title":"Echocardiography"},{"issue":"1","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.115.002530","article-title":"Diagnostic accuracy of tissue Doppler index E\/e\u2019 for evaluating left ventricular filling pressure and diastolic dysfunction\/heart failure with preserved ejection fraction: a systematic review and meta\u2010analysis","volume":"5","author":"Sharifov OF","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.779223"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.12.037"},{"key":"e_1_2_9_18_1","first-page":"1","article-title":"When does the E\/e\u2019 index not work? 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