{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:15:41Z","timestamp":1790039741294,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the left ventricular (LV) systolic strain by four\u2010dimensional speckle tracking echocardiography (4D\u2010STE) in order to provide the early detection of myocardial dysfunction in patients with Sj\u00f6gren's syndrome (SS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty consecutive patients with primary SS diagnosed at the rheumatology outpatient clinic and 35 age\u2010 and sex\u2010matched healthy volunteers were included in the study. 4DSTE was performed, and global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were measured. 4DSTE results were compared with the healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were observed between the GRS and GCS values of the two groups. A significant difference was observed in the GLS and GAS measurements between the two groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005 for GLS, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 for GAS). Positive correlation was detected between disease duration and LV\u2010GLS and LV\u2010GAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We demonstrated subclinical systolic dysfunction in SS patients by 4DSTE, which is a sensitive marker of ventricular dysfunction. Deterioration of the LV became more evident as duration of the disease increased. Therefore, we believe that a cardiac evaluation will be of benefit to patients with long\u2010term SS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14867","type":"journal-article","created":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T12:14:12Z","timestamp":1600604052000},"page":"1803-1808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Subclinical left ventricular dysfunction in Sj\u00f6gren\u2019s syndrome assessed by four\u2010dimensional speckle tracking echocardiography"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9174-6777","authenticated-orcid":false,"given":"J\u00fclide","family":"Akaycan","sequence":"first","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4103-9345","authenticated-orcid":false,"given":"\u015e\u0131ho","family":"Hidayet","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6523-9130","authenticated-orcid":false,"given":"Adil","family":"Bayramo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Servet","family":"Yolba\u015f","sequence":"additional","affiliation":[{"name":"Department of Rheuomatology Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u00fccel","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakup","family":"Yi\u011fit","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Inonu University Malatya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Uluta\u015f","sequence":"additional","affiliation":[{"name":"Department of Cardiology Elaz\u0131\u011f Fethi Sekin City Hosp\u0131tal Elaz\u0131\u011f Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"465","article-title":"Diagnosis and management of Sj\u00f6gren syndrome","volume":"79","author":"Kruszka P","year":"2009","journal-title":"Am Fam Physician"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00005792-200207000-00003","article-title":"Primary Sj\u00f6gren 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