{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:07:58Z","timestamp":1792192078863,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We examined the left atrial stiffness index (LA Stiff) on echocardiography and its determinants in adults and adolescents with repaired congenital left ventricular outflow obstructions (c\u2010LVOOs), including isolated subaortic stenosis (SAS), stenotic bicuspid aortic valve (BAV), and aortic coarctation (CoA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010two patients (43 males, age: 31\u00a0\u00b1\u00a015\u00a0years) with repaired c\u2010LVOOs (SAS: n\u00a0=\u00a012; BAV: n\u00a0=\u00a027; CoA: n\u00a0=\u00a033) were compared to 72 age\u2010 and sex\u2010matched controls. 2D strain imaging was performed to assess left ventricular (LV) and LA function, including peak positive longitudinal LA strain (LAS), late diastolic LA strain (LDS), and LV global longitudinal strain (GLS). The (E\/Ea)\/LAS ratio was used to calculate LA Stiff.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LA Stiff was significantly higher in the c\u2010LVOO group than in the control group. Among the c\u2010LVOO patients, the CoA group had the lowest GLS and the highest LA Stiff; no significant differences were found with respect to sex, hypertension history, smoking status, or repeated repair among c\u2010LVOO subtypes. Multivariable regression analysis with the variables \u201cBMI\u201d and \u201cc\u2010LVOO subtype\u201d revealed that BMI and c\u2010LVOO subtypes were independently associated with LA Stiff (b\u00a0=\u00a00.290, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.009 and b\u00a0=\u00a00.353, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We documented abnormal LA Stiff values in adults and adolescents after c\u2010LVOO repair. Patients with CoA demonstrated the most impaired LA Stiff values. Overweight may contribute to worse LA Stiff values. Further studies are required to determine the prognostic implications of LA Stiff in patients with repaired c\u2010LVOOs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14925","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T12:01:19Z","timestamp":1605096079000},"page":"47-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impaired left atrial stiffness in patients with corrected congenital left ventricular outflow obstructions"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4435-4401","authenticated-orcid":false,"given":"Fabien","family":"Labombarda","sequence":"first","affiliation":[{"name":"Department of Cardiology CHU de Caen Caen France"},{"name":"Medical School Universit\u00e9 Caen Normandie UNICAEN, CHU Caen Caen 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