{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:00:22Z","timestamp":1781661622793,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T00:00:00Z","timestamp":1610409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01 HL137360\u201002"],"award-info":[{"award-number":["P01 HL137360\u201002"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1 AG017479"],"award-info":[{"award-number":["RO1 AG017479"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Age\u2010related changes to left ventricular (LV) early diastolic recoil confound the diagnostic value of e\u2032 velocity in heart failure with preserved ejection fraction (HFpEF). Systolic\u2013diastolic coupling quantifies passive left ventricular elastic recoil and may be superior to e\u2032 in differentiating abnormal diastolic recoil in HFpEF from healthy aging. This study aims to determine the effect of healthy aging and HFpEF on systolic\u2013diastolic coupling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy adults (n\u00a0=\u00a0141, aged 20\u201090\u00a0years) underwent right heart catheterization (RHC) to quantify LV filling pressure and tissue Doppler echocardiography to define peak velocities and excursion (velocity time integral) of the mitral annulus. Separately, HFpEF patients (n\u00a0=\u00a012, age 67\u00a0\u00b1\u00a05\u00a0years) and controls (n\u00a0=\u00a012, age 68\u00a0\u00b1\u00a05\u00a0years) underwent RHC and echocardiography. Systolic\u2013diastolic coupling was measured as early diastolic excursion (ED<jats:sub>exc<\/jats:sub>) divided by systolic excursion (S<jats:sub>exc<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In healthy adults, ED<jats:sub>exc<\/jats:sub>\/ S<jats:sub>exc<\/jats:sub> declined by 15% per decade of life (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.53, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). ED<jats:sub>exc<\/jats:sub>\/S<jats:sub>exc<\/jats:sub> was significantly lower in HFpEF compared with controls (0.43\u00a0\u00b1\u00a00.11 vs 0.56\u00a0\u00b1\u00a00.11, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011), while e\u2032 was similar (6.2\u00a0\u00b1\u00a01.5 vs 6.8\u00a0\u00b1\u00a01.3\u00a0cm\/s, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.33). Using ROC analysis, ED<jats:sub>exc<\/jats:sub>\/S<jats:sub>exc<\/jats:sub> had an AUC to detect HFpEF of 0.82 (0.61\u20100.95, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007), which was superior to e\u2032 alone (AUC 0.60(0.39\u20100.80), <jats:italic>P<\/jats:italic>\u00a0=\u00a0.39; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.026 for difference).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Systolic\u2013diastolic coupling, quantified by the ED<jats:sub>exc<\/jats:sub>\/S<jats:sub>exc<\/jats:sub> ratio, declined linearly with healthy aging. The ED<jats:sub>exc<\/jats:sub>\/S<jats:sub>exc<\/jats:sub> ratio was further reduced in HFpEF and able to predict HFpEF more accurately than e\u2032 alone. Systolic\u2013diastolic coupling may be a useful diagnostic tool to detect HFpEF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.14975","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T11:38:46Z","timestamp":1610710726000},"page":"261-270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of systolic\u2013diastolic coupling in distinguishing impaired diastolic recoil in healthy aging and heart failure with preserved ejection fraction"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-6021","authenticated-orcid":false,"given":"James P.","family":"MacNamara","sequence":"first","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas TX USA"},{"name":"University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Koshti","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Jou","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas TX USA"},{"name":"Tri\u2010Service General Hospital National Defense Medical Center Taiwan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin A.","family":"Dias","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas TX USA"},{"name":"University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Christopher M.","family":"Hearon","sequence":"additional","affiliation":[{"name":"Institute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas TX USA"},{"name":"University of Texas Southwestern Medical Center Dallas TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"3rd","given":"William","family":"Cornwell","sequence":"additional","affiliation":[{"name":"University of Colorado Anschutz Medical Campus Aurora Aurora CO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin J.","family":"Howden","sequence":"additional","affiliation":[{"name":"Baker Heart and Diabetes Institute Melbourne Vic. 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