{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:01:28Z","timestamp":1768402888127,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T00:00:00Z","timestamp":1613260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Complications of bicuspid aortic valve commonly include aortic stenosis, aortic regurgitation, and ascending aortic dilation. The progression of these lesions is not well described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We reviewed 249 bicuspid aortic valve patients with at least two echocardiograms from 2006 to 2016. Valve morphology (right\u2013left or right\u2013noncoronary cusp fusion) was confirmed by visual inspection, and aortic stenosis and regurgitation were quantified according to current guidelines; the ascending aorta was measured at end\u2010systole 2\u20133\u00a0cm above the sinotubular junction. Annualized progression of stenosis, regurgitation, and aortic dilation from first to most recent echocardiogram were compared between right\u2013left and right\u2013nonfused valves using multivariable logistic regression to adjust for baseline differences in groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 249 bicuspid aortic valve patients (mean age 47.6\u00a0\u00b1\u00a013.5\u00a0years, 66.3% male), 75.9% had right\u2013left cusp fusion. At baseline, aortic stenosis was absent or mild in 80.3%; aortic regurgitation was absent or mild in 80.7%; and aortic diameters were 35.0\u00a0\u00b1\u00a05.7\u00a0mm (sinuses of Valsalva) and 37.4\u00a0\u00b1\u00a06.2\u00a0mm (ascending). Mean annualized decrease in aortic valve area was 0.07\u00a0cm<jats:sup>2<\/jats:sup>\/year, with 30% of bicuspid aortic valve patients progressing \u22650.1\u00a0cm<jats:sup>2<\/jats:sup>\/year. Aortic regurgitation progressed \u22651 grade in 37 patients. Mean annualized increase in ascending aorta diameter was 0.36\u00a0mm\/year in right\u2013left and 0.65\u00a0mm\/year in right\u2013nonbicuspid valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this serial echocardiographic study of bicuspid aortic valve patients, cusp orientation was not associated with progression of valve dysfunction. Right\u2013noncoronary cusp fusion was associated with ascending aortic diameter progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15000","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T15:11:33Z","timestamp":1613574693000},"page":"394-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serial echocardiography for valve dysfunction and aortic dilation in bicuspid aortic valves"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-3742","authenticated-orcid":false,"given":"Matthew W.","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiovascular Diseases University of Massachusetts Medical Center Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee Dallasen","family":"Muchnik","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology University of Rochester Medical Center Rochester NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adedotun","family":"Ogunsua","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiovascular Diseases University of Massachusetts Medical Center Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amartya","family":"Kundu","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiovascular Diseases University of Massachusetts Medical Center Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvasini","family":"Lakshmanan","sequence":"additional","affiliation":[{"name":"Lundquist Institute at Harbor\u2010UCLA Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Florida Health Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6589-6336","authenticated-orcid":false,"given":"John B.","family":"Dickey","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiovascular Diseases University of Massachusetts Medical Center Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryon A.","family":"Gentile","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiovascular Diseases University of Massachusetts Medical Center Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda A.","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiovascular Diseases University of Massachusetts Medical Center Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.740878"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.9.2262"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007851"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.537"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.11.020"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.02.009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.11.1317"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004211"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155623.48408.C5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90799-I"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"e005987","DOI":"10.1161\/CIRCIMAGING.117.005987","article-title":"Bicuspid aortic valve","volume":"10","author":"Kong WKF","year":"2018","journal-title":"circulation cardiovasc. 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