{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:01:46Z","timestamp":1747184506721,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T00:00:00Z","timestamp":1614988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dobutamine\u2010atropine stress echocardiography (DSE) has lower sensitivity in patients with advanced liver disease (ALD) due to vasodilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Hypothesis<\/jats:title><jats:p>Dopamine\u2010atropine stress echocardiography (DopSE) may be an alternative to DSE in ALD patients by improving the blood pressure response to stress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The safety and tolerability of DSE and DopSE were compared in 10 volunteers. The safety, adverse effects, and efficacy of DopSE were then assessed in 105 patients, 98 of whom had ALD. Dopamine was infused in stepwise fashion from 5\u00a0\u00b5g\/kg\/min to a peak dose of 40\u00a0\u00b5g\/kg\/min. Atropine was given before and in early stages of dopamine infusion up to cumulative dose of 1.5\u00a0mg. The hemodynamic responses of 98 ALD patients were compared with 102 patients with ALD who underwent standard DSE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In normal volunteers, systolic BP increased more with DopSE compared to DSE (61\u00a0\u00b1\u00a019\u00a0mm\u00a0Hg vs 39\u00a0\u00b1\u00a015\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008). In 105 patients who underwent DopSE, none had adverse effects that required early stress termination. In the groups with ALD, the systolic BP increase (38\u00a0\u00b1\u00a028\u00a0mm\u00a0Hg vs 12\u00a0\u00b1\u00a027\u00a0mm\u00a0Hg, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and peak rate pressure product (RPP) (22\u00a0861\u00a0\u00b1\u00a05289 vs 17\u00a0211\u00a0\u00b1\u00a03848, <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;.001) were both higher in those undergoing DopSE versus DSE. The sensitivity and specificity of DopSE were 45% and 88%, respectively for coronary disease (\u226570% stenosis) in 37 patients who had angiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Dopamine\u2010atropine stress echocardiography appears to be a safe stress modality and provides greater increases in RPP in patients with ALD compared to DSE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15020","type":"journal-article","created":{"date-parts":[[2021,3,6]],"date-time":"2021-03-06T13:04:35Z","timestamp":1615035875000},"page":"568-573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and feasibility of dopamine\u2010atropine stress echocardiography"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-7104","authenticated-orcid":false,"given":"Abhishek","family":"Khemka","sequence":"first","affiliation":[{"name":"Krannert Institute of Cardiology Indiana Health Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roopa A","family":"Rao","sequence":"additional","affiliation":[{"name":"Krannert Institute of Cardiology Indiana Health Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqas","family":"Ghumman","sequence":"additional","affiliation":[{"name":"Florida Heart and Vascular JFK Medical Center Atlantis FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jothiharan","family":"Mahenthiran","sequence":"additional","affiliation":[{"name":"Division of Cardiology Community Health Network Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey","family":"Feigenbaum","sequence":"additional","affiliation":[{"name":"Krannert Institute of Cardiology Indiana Health Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Sawada","sequence":"additional","affiliation":[{"name":"Krannert Institute of Cardiology Indiana Health Indiana University School of Medicine Indianapolis IN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.5.1605"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00376-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80795-4"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.10.031"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91754-1"},{"key":"e_1_2_8_7_1","first-page":"698","article-title":"Dobutamine infusion in conscious dogs with and without autonomic nervous system inhibition: effects of systemic 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