{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:28Z","timestamp":1787014108032,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>Complex aortic atheroma (CAA) is a common cause of acute brain ischemia (BI), including ischemic stroke (IS) and transient ischemic attack (TIA), and is associated with recurrence. The CHA2DS2\u2010VASc score is a useful tool for predicting stroke in patients with atrial fibrillation (AF), and can also predict cardiovascular events in other populations, including non\u2010AF populations. The ADAM\u2010C score is a new risk score for predicting the diagnostic yield of transesophageal echocardiography (TEE) after BI. We aimed to evaluate the ability of CHA2DS2\u2010VASc and ADAM\u2010C scores to predict CAA after BI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicenter, observational study included 1479 patients aged over 18\u00a0years who were hospitalized for BI. CAA was defined as the presence of one or more of the following criteria: thrombus, ulcerated plaque, or plaque thickening\u00a0\u2265\u00a04\u00a0mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAA was diagnosed in 216 patients (14.6%). CHA2DS2\u2010VASc and ADAM\u2010C scores were significantly higher in the CAA group versus the non\u2010CAA group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.0001 for both). The CHA2DS2\u2010VASc and ADAM\u2010C scores appear to be good predictors of CAA (AUC 0.699 [0.635, 0.761] and 0.759 [0.702, 0.814], respectively). The sensitivity, specificity, predictive positive value (PPV), and negative predictive value (NPV) of the scores for detecting CAA were 94%, 22%, 17%, and 96%, respectively, for a CHA2DS2\u2010VASc score\u00a0&lt;\u00a02, and 90%, 46%, 22%, and 96%, respectively, for an ADAM\u2010C score\u00a0&lt;\u00a03\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CHA2DS2\u2010VASc and ADAM\u2010C scores are able to predict CAA after BI. CHA2DS2\u2010VASc\u00a0&lt;\u00a02 and ADAM\u2010C\u00a0&lt;\u00a03 both have an interesting NPV of 96%.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.15034","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T05:56:24Z","timestamp":1616651784000},"page":"612-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of ADAM\u2010C and CHA2DS2\u2010VASc scores to predict complex aortic atheroma after brain ischemia: A prospective observational study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6265-4216","authenticated-orcid":false,"given":"Florence","family":"Nicot","sequence":"first","affiliation":[{"name":"Department of Cardiology Versailles Hospital Le Chesnay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9267-7227","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Charbonnel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Versailles Hospital Le Chesnay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Jego","sequence":"additional","affiliation":[{"name":"Department of Cardiology Toulon inter\u2010arm\u00e9e Hospital Toulon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Jourda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Auxerre Hospital Auxerre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulric","family":"Vinsonneau","sequence":"additional","affiliation":[{"name":"Department of Cardiology Brest inter\u2010arm\u00e9e Hospital Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gar\u00e7on","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saint Joseph Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Turlotte","sequence":"additional","affiliation":[{"name":"Department of Cardiology La Roche sur Yon Hospital La Roche sur Yon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Fran\u00e7ois","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Cardiology Pau Hospital Pau France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Maurin","sequence":"additional","affiliation":[{"name":"Department of Cardiology CHU Grenoble\u2010Alpes Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Lubret","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boulogne sur mer Hospital Boulogne sur mer France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Meimoun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Compi\u00e8gne Hospital Compi\u00e8gne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrystelle","family":"Akret","sequence":"additional","affiliation":[{"name":"Department of Cardiology Annecy\u2010Genevois Hospital Annecy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Cournot","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saint Paul Hospital Saint Paul France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Sokic","sequence":"additional","affiliation":[{"name":"Department of Cardiology Haguenau Hospital Haguenau France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Michel","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saint Lo Hospital Saint Lo France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lescure","sequence":"additional","affiliation":[{"name":"Department of Cardiology Auch Hospital Auch France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kenizou","sequence":"additional","affiliation":[{"name":"Department of Cardiology Mulhouse Hospital Mulhouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Melay","sequence":"additional","affiliation":[{"name":"Department of Cardiology Vichy Hospital Vichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Fayard","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chalon sur Saone Hospital Chalon sur Saone France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Chauvat","sequence":"additional","affiliation":[{"name":"Department of Cardiology Argenteuil Hospital Argenteuil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Fouch\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology Montb\u00e9liard Hospital Montb\u00e9liard France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Cartigny","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beaune Hospital Beaune France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dijoux","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saint Pierre Hospital Saint Pierre France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C\u00e9line","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Cardiology European Georges Pompidou Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lia","family":"Tho\u2010Agostini","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bastia Hospital Bastia France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Cardiology Voiron Hospital Voiron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Magnin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Dole Hospital Dole France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Goralski","sequence":"additional","affiliation":[{"name":"Department of Cardiology Orl\u00e9ans Hospital Orl\u00e9ans France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pico","sequence":"additional","affiliation":[{"name":"Department of Cardiology Versailles Hospital Le Chesnay France"},{"name":"Department of Neurology Universit\u00e9 Versailles Saint\u2010Quentin en Yvelines et Paris Saclay Le Chesnay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Georges","sequence":"additional","affiliation":[{"name":"Department of Cardiology Versailles Hospital Le Chesnay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Belle","sequence":"additional","affiliation":[{"name":"Department of Cardiology Annecy\u2010Genevois Hospital Annecy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00806-3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199605093341902"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.09.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq045"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.153544"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000024"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.07.025"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199412013312202"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.6.1560"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.17.2087"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(01)02225-1"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2014.05.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/2048872616673536"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.11.004"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10725"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318287281b"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2019.03.009"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jebm.12113"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.004251"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.811935"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215340"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.4052"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.10.007"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801174"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410489"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910355"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.15034","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T21:20:07Z","timestamp":1693603207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.15034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/echo.15034"],"URL":"https:\/\/doi.org\/10.1111\/echo.15034","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,25]]},"assertion":[{"value":"2020-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}