{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:08:29Z","timestamp":1779167309827,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T00:00:00Z","timestamp":1619740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies have found conflicting results concerning the left ventricular (LV) myocardial deformation properties in patients with normally functioning bicuspid aortic valves (BAVs). Whether the remodeling process of LV occurs independently in patients with BAV is a matter of debate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We searched PubMed, Embase, Cochrane library, and Web of Science for cohort studies aiming to assess LV function in adults with isolated BAV compared with tricuspid aortic valve (TAV) controls. Standard mean difference (SMD) was calculated from random\u2010effects meta\u2010analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight cohort studies were included. There were significantly lower global longitudinal strain (GLS), global radial strain (GRS), global circumferential strain (GCS) in BAV than in TAV controls (GLS: SMD\u00a0=\u00a00.64, 95% CI: 0.35 to 0.92, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001; GRS: SMD\u00a0=\u00a0\u22120.71, 95% CI: \u22121.09 to \u22120.32, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0003; GCS: SMD\u00a0=\u00a00.70, 95% CI: 0.41 to 0.98, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.00001) and significantly higher left atrial volume index (LAVI) and E\/e\u2019 in BAV than in TAV controls (LAVI: SMD\u00a0=\u00a00.50, 95% Cl: 0.12 to 0.88, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01; E\/e\u2019: SMD\u00a0=\u00a00.54, 95% CI: 0.30 to 0.77, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.00001). There was significantly higher Left ventricular mass index\uff08LVMI\uff09 in BAV than in TAV controls (SMD\u00a0=\u00a00.51, 95% CI: 0.24 to 0.79, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0003). Left ventricular ejection fraction (LVEF) was not significantly different between BAV patients and TAV controls (SMD\u00a0=\u00a00.05, 95% CI: \u22120.16 to 0.26, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.63).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The impairment of LV myocardial mechanics, including LV systolic, diastolic dysfunction and LV hypertrophy, is present in patients with normally functioning BAV.\u00a0This might support the hypothesis that BAV is not only a valvular disease but also a myocardial disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15042","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T13:19:47Z","timestamp":1619788787000},"page":"834-843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of left ventricular myocardial mechanics in patients with normally functioning bicuspid aortic valves: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Huiyun","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Affiliated Hospital of China Medical University Shenyang Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Affiliated Hospital of China Medical University Shenyang Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Affiliated Hospital of China Medical University Shenyang Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongze","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Affiliated Hospital of China Medical University Shenyang Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Affiliated Hospital of China Medical University Shenyang Liaoning Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9255-3475","authenticated-orcid":false,"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Ultrasound The First Affiliated Hospital of China Medical University Shenyang Liaoning Province 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