{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:12:16Z","timestamp":1786389136693,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze global left ventricular longitudinal strain (GLS), mechanical dispersion (MD), electrocardiographic repolarization, and myocardial injury markers changes during androgen deprivation therapy (ADT) and subsequent hypogonadism in men with advanced prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 31 patients 69.7\u00a0\u00b1\u00a07.3\u00a0years old, in sinus rhythm, with stable cardiac conditions and evaluated them by echocardiography, electrocardiography, and blood sampling for high sensitivity cardiac troponin I (hs\u2010cTnI), and N\u2010terminal pro\u2010brain natriuretic peptide (NTproBNP), at ADT initiation (M0) and after 6\u00a0months of treatment (M1). Peak longitudinal strain by speckle\u2010tracking echocardiography was assessed in 17 left ventricular segments and averaged to GLS. Standard deviation of time intervals from the start of Q\/R on electrocardiogram to peak longitudinal strain in the 17 segments (MD<jats:sub>SD<\/jats:sub>), and the difference between the longest and shortest time\u2010to\u2010peak strain intervals (MD<jats:sub>delta<\/jats:sub>) were calculated as indices of MD. Fridericia corrected electrocardiographic repolarization parameters were analyzed as follows: QT interval (QTc), mean and maximum values of Tpeak\u2010Tend interval (Tpe), and Tpe\/QT ratio, Tpe dispersion (Tped).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant impairments of the following parameters were registered between M0 and M1: GLS (%) (\u221216.93\u00a0\u00b1\u00a03.89; \u221214.43\u00a0\u00b1\u00a03.57, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), MD<jats:sub>SD<\/jats:sub> (ms) (77.4\u00a0\u00b1\u00a021.4; 89\u00a0\u00b1\u00a027, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004), MD<jats:sub>delta<\/jats:sub> (ms) (225.3\u00a0\u00b1\u00a078.3; 259.9\u00a0\u00b1\u00a0108.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), QTc (ms) (458.8\u00a0\u00b1\u00a043.4; 485.6\u00a0\u00b1\u00a045.1, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), maxTpe\/QT (0.246\u00a0\u00b1\u00a00.04; 0.268\u00a0\u00b1\u00a00.04, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), maxTpe (ms) (105.4\u00a0\u00b1\u00a023.2; 119.5\u00a0\u00b1\u00a026.4 <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01), meanTpe (ms) (83.3\u00a0\u00b1\u00a016.8; 90.7\u00a0\u00b1\u00a019.3, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), and hs\u2010cTnI (ng\/mL) (4.6\u00a0\u00b1\u00a05.4; 5.4\u00a0\u00b1\u00a06.4, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Mean serum testosterone level at M1 was 0.1\u00a0\u00b1\u00a00.13\u00a0ng\/mL. The patients\u2019 clinical cardiological status remained stable during follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ADT and subsequent hypogonadism induce subclinical alterations in GLS, MD, electrocardiographic repolarization parameters, and hs\u2010cTnI during the first 6\u00a0months of treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15043","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T09:52:12Z","timestamp":1616665932000},"page":"632-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Subclinical left ventricular dysfunction in men under androgen deprivation therapy for prostate cancer, revealed by speckle\u2010tracking\u2010derived parameters, repolarization, and myocardial injury markers"],"prefix":"10.1111","volume":"38","author":[{"given":"Andrei C. D.","family":"Gheorghe","sequence":"first","affiliation":[{"name":"Faculty of Medicine Carol Davila University of Medicine and Pharmacy Bucharest Romania"},{"name":"Department of Internal Medicine and Cardiology Theodor Burghele Clinical Hospital Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9718-0121","authenticated-orcid":false,"given":"Ana","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Carol Davila University of Medicine and Pharmacy Bucharest Romania"},{"name":"Department of Internal Medicine and Cardiology Theodor Burghele Clinical Hospital Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea S.","family":"Hodorogea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Carol Davila University of Medicine and Pharmacy Bucharest Romania"},{"name":"Department of Internal Medicine and Cardiology Theodor Burghele Clinical Hospital Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Radavoi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Carol Davila University of Medicine and Pharmacy Bucharest Romania"},{"name":"Department of Urology Theodor Burghele Clinical Hospital Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viorel","family":"Jinga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Carol Davila University of Medicine and Pharmacy Bucharest Romania"},{"name":"Department of Urology Theodor Burghele Clinical Hospital Bucharest Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru S. 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