{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:52:56Z","timestamp":1790117576014,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Calcific aortic stenosis (AS) is a common valvular disease especially in elderly population. Inflammation plays significant role in the pathophysiological mechanism. Systemic immune\u2010inflammation index (SII) is a novel marker of immune system and inflammation that includes neutrophil, lymphocyte, and platelet cell counts. The aim of this study was to investigate the predictive value of SII in calcific severe AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Severe calcific AS patients were categorized into two groups: High flow\u2010high gradient (HFHG) AS (n\u00a0=\u00a0289) and low flow\u2010low gradient AS (n\u00a0=\u00a079). Control group included 273 patients with similar clinical and demographic characteristics but without AS. SII was calculated as absolute platelet count\u00a0\u00d7\u00a0absolute neutrophil count\/absolute lymphocyte count.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SII levels were 525\u00a0\u00b1\u00a0188, 835\u00a0\u00b1\u00a0402, and 784\u00a0\u00b1\u00a0348 in control, HFHG AS, and LFLG AS groups, respectively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Correlation analyses revealed significant and positive correlation between SII and mean aortic transvalvular pressure gradient (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.342, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), and negative and significant correlation between SII and AVA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.461, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Multivariate analysis performed in separate models demonstrated sex, CAD, LDL, and SII levels (Odds ratio [OR]: 1.004, 95 CI%:1.003\u20131.004) as independent predictors of severe AS in Model 1. According to Model 2, sex, CAD, LDL, and high SII (&gt;661) (OR:5.78, 95 CI%:3.93\u20134.89) remained as independent predictors of severe AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SII levels can be useful to predict severe calcific AS patients and significantly correlate with AVA and mean aortic transvalvular pressure gradient.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15044","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T06:00:29Z","timestamp":1616824829000},"page":"737-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The relationship between calcific severe aortic stenosis and systemic immune\u2010inflammation index"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-3823","authenticated-orcid":false,"given":"Mehmet","family":"Erdo\u011fan","sequence":"first","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Ankara Turkey"},{"name":"Department of Cardiology Ministry of Health Ankara Bilkent City Hospital Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sel\u00e7uk","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Yozgat Bozok University Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"Karde\u015fler","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University Ankara 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