{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:24:00Z","timestamp":1757701440179,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pericardial effusion drainage in patients with significant pulmonary hypertension (PH) has been questioned because of hemodynamic collapse concern, mainly because of right ventricular (RV) function challenging assessment. We aimed to assess RV function changes related to pericardiocentesis in patients with and without PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with symptomatic moderate\u2010to\u2010large pericardial effusion who had either echocardiographic or clinical signs of cardiac tamponade and who underwent pericardiocentesis from 2013 to 2018 were included. RV speckle\u2010tracking echocardiography analysis was performed before and after pericardiocentesis. Patients were stratified by significant PH (pulmonary artery systolic pressure [PASP] \u226550\u00a0mm\u00a0Hg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort consisted of 76 patients, 23 (30%) with PH. In patients with PH, both end\u2010diastolic and end\u2010systolic areas (EDA, ESA) increased significantly after pericardiocentesis (22.6\u00a0\u00b1\u00a08.0\u00a0cm<jats:sup>2<\/jats:sup>\u201326.4\u00a0\u00b1\u00a08.4\u00a0cm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) and (15.9\u00a0\u00b1\u00a06.3\u00a0cm<jats:sup>2<\/jats:sup>\u201318.7\u00a0\u00b1\u00a06.5\u00a0cm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), respectively. However, RV function indices including fractional area change (FAC: 30.6\u00a0\u00b1\u00a013.7%\u201329.1\u00a0\u00b1\u00a08.8%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.61) and free\u2010wall longitudinal strain (FWLS: \u221216.7\u00a0\u00b1\u00a06.7 to \u221215.9\u00a0\u00b1\u00a05.0, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.50) remained unchanged postpericardiocentesis. In contrast, in the non\u2010PH group, after pericardiocentesis, EDA increased significantly (20.4\u00a0\u00b1\u00a06.2\u201322.4\u00a0\u00b1\u00a05.9 cm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006) but ESA did not (14.9\u00a0\u00b1\u00a05.7 vs 15.0\u00a0\u00b1\u00a04.6\u00a0cm<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.89), and RV function indices improved (FAC 27.9\u00a0\u00b1\u00a011.7%\u201333.1\u00a0\u00b1\u00a08.5%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003; FWLS \u221213.6\u00a0\u00b1\u00a05.4 to \u221217.2\u00a0\u00b1\u00a03.9%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Quantification of RV size and function can improve understanding of echocardiographic and hemodynamic changes postpericardiocentesis, which has the potential to guide management of PH patients with large pericardial effusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15046","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T13:12:30Z","timestamp":1617973950000},"page":"752-759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pericardiocentesis induced right ventricular changes in patients with and without pulmonary hypertension"],"prefix":"10.1111","volume":"38","author":[{"given":"Hilmi","family":"Alnsasra","sequence":"first","affiliation":[{"name":"MedStar Heart and Vascular Institute MedStar Washington Hospital Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian C.","family":"Case","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medicine MedStar Georgetown University Hospital Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby","family":"Rogers","sequence":"additional","affiliation":[{"name":"MedStar Heart and Vascular Institute MedStar Washington Hospital Center Washington DC USA"},{"name":"Cardiovascular Branch Division of Intramural Research National Heart, Lung and Blood Institute National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lowell F.","family":"Satler","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico M.","family":"Asch","sequence":"additional","affiliation":[{"name":"MedStar Health Research 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