{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:45:54Z","timestamp":1784958354613,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective<\/jats:bold>: Prematurity and bronchopulmonary dysplasia (BPD) are associated with poorly understood abnormalities of ventricular function. We therefore comprehensively compared biventricular function in infants with and without BPD.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: Prospective observational study in extremely preterm infants with (<jats:italic>n<\/jats:italic>\u00a0=\u00a020) and without (<jats:italic>n<\/jats:italic>\u00a0=\u00a038) BPD using conventional and advanced echocardiography at 28 days (T1) and near\u2010term (T2).<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Infants with BPD had lower birth gestational age (26.7\u00b11.9\u00a0vs 27.4\u00b11.1\u00a0weeks, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047) and weight (884\u00b1207\u00a0vs 1108\u00b1190\u00a0g, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0001). BPD was associated with larger right ventricles (RV) and reduced RV systolic strain rate at T1 and pulmonary hypertensive indicators at T2 (pulmonary artery acceleration time BPD 51\u00b117\u00a0vs no BPD 63\u00b112\u00a0ms, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017). At T1\/T2, infants with BPD had lower RV tissue Doppler velocities (e\u2019, a\u2019 and s) and higher E\/e\u2019 ratios (T1: BPD 10.4\u00b12.4\u00a0vs no BPD 6.2\u00b13.1\u00a0cm\/sec, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001; T2: BPD 8.0\u00b13.1\u00a0vs no BPD 5.6\u00b12.6\u00a0cm\/sec, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), altered LV diastolic function (apical circumferential T1 early diastolic strain rate BPD 2.8\u00b10.8\u00a0vs no BPD 3.6\u00b11.0\u00a0\/sec, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04; T2 late diastolic strain rate, BPD 2.29 \u00b1 0.99\u00a0vs no BPD 1.67\u00b10.84\u00a0\/sec, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) and LV rotational mechanics (T1: twist rate BPD 90\u00b116\u00a0vs no BPD 130\u00b148\u00a0deg\/sec<jats:sup>,<\/jats:sup> <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008; untwist rate (UTR) BPD \u201069\u00b190\u00a0vs no BPD \u2010147\u00b168\u00a0deg\/sec, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008; torsion BPD 2.78\u00b10.56\u00a0vs no BPD 4.48\u00b11.74\u00a0deg\/cm, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.009; and T2: UTR BPD \u2010132\u00b169\u00a0vs no BPD \u2010179\u00b157\u00a0deg\/sec, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.013).<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: BPD is associated with altered RV diastolic function that persists near term, with elevated pulmonary vascular resistance, and with persistent alterations in LV apical strain rate and rotational mechanics.<\/jats:p>","DOI":"10.1111\/echo.15178","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T05:14:54Z","timestamp":1631250894000},"page":"1596-1603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Influence of extreme prematurity and bronchopulmonary dysplasia on cardiac function"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3665-1142","authenticated-orcid":false,"given":"Jose Carlos","family":"Aldana\u2010Aguirre","sequence":"first","affiliation":[{"name":"Division of Neonatology Stollery Children's Hospital  Edmonton Alberta Canada"},{"name":"SickKids Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Eckersley","sequence":"additional","affiliation":[{"name":"Fetal &amp; Neonatal Cardiology Program Division of Cardiology Department of Pediatrics Stollery Children's Hospital  Edmonton Alberta Canada"},{"name":"Women's &amp; Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Hyderi","sequence":"additional","affiliation":[{"name":"Division of Neonatology Stollery Children's Hospital  Edmonton Alberta 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