{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:43:08Z","timestamp":1777984988382,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2013\u201023897\u2010104604\u201023"],"award-info":[{"award-number":["2013\u201023897\u2010104604\u201023"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["523\u20102014\u20102336"],"award-info":[{"award-number":["523\u20102014\u20102336"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple echocardiographic algorithms have been proposed to estimate mean pulmonary artery pressure (PAP<jats:sub>M<\/jats:sub>) and assess pulmonary hypertension (PH) likelihood. We assessed the accuracy of four echocardiographic approaches to estimate PAP<jats:sub>M<\/jats:sub> in heart failure (HF) patients undergoing near\u2010simultaneous right heart catheterization (RHC), and compared diagnostic performance to identify PH with recommendation\u2010advised tricuspid regurgitation peak velocity (TRV<jats:sub>max<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We employed four validated echocardiographic algorithms incorporating tricuspid regurgitation peak or mean gradient, pulmonary regurgitation peak gradient, and right ventricular outflow tract acceleration time to estimate PAP<jats:sub>M<\/jats:sub>. Echocardiographic estimates of right atrial pressure were incorporated in all algorithms but one. Association and agreement with invasive PAP<jats:sub>M<\/jats:sub> were assessed. Diagnostic performance of all algorithms to identify PH was evaluated and compared with the recommended TRV<jats:sub>max<\/jats:sub> cut\u2010off.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 112 HF patients, all echocardiographic algorithms demonstrated reasonable association (r\u00a0=\u00a0.41\u2013.65; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and good agreement with invasive PAP<jats:sub>M<\/jats:sub>, with relatively lower mean bias and higher precision observed in algorithms that incorporated tricuspid regurgitation peak or mean gradient. All methods demonstrated strong ability to identify PH (AUC\u00a0=\u00a0.70\u2013.80; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) but did not outperform TRV<jats:sub>max<\/jats:sub> (AUC\u00a0=\u00a0.84; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Echocardiographic estimates of right atrial pressure were falsely elevated in 30% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Echocardiographic estimates demonstrate reasonable association with invasive PAP<jats:sub>M<\/jats:sub> and strong ability to identify PH in HF. However, none of the algorithms outperformed recommendation\u2010advised TRV<jats:sub>max<\/jats:sub>. The incremental value of echocardiographic estimates of right atrial pressure may need to be re\u2010evaluated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15188","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T17:11:10Z","timestamp":1631466670000},"page":"1624-1631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Accuracy and diagnostic performance of doppler echocardiography to estimate mean pulmonary artery pressure in heart failure"],"prefix":"10.1111","volume":"38","author":[{"given":"Alva","family":"Bj\u00f6rkman","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars H.","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Unit, Department of Clinical Physiology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrika Ljung","family":"Fax\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Unit, Department of Clinical Physiology Karolinska Institutet  Stockholm Sweden"},{"name":"Perioperative Medicine and Intensive Care Karolinska University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Lindquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Surgical &amp; Perioperative sciences Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-0604","authenticated-orcid":false,"given":"Ashwin","family":"Venkateshvaran","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Unit, Department of Clinical Physiology Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.085761"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv512"},{"key":"e_1_2_8_4_1","article-title":"Pulmonary hypertension in heart failure patients","volume":"6","author":"Rao SD","year":"2020","journal-title":"Cardiac Fail Rev"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913-2018"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30498-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.04.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.2.302"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.08.037"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.4.1313"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015670"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91189-1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2013.01.006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)91189-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200811-1691OC"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1269"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.07.005"},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"Accuracy of echocardiographic estimates of pulmonary artery pressures in pulmonary hypertension: insights from the KARUM hemodynamic database","author":"Venkateshvaran A","year":"2021","journal-title":"Int J Cardiovasc Imag"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0904"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.09.009"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.02.005"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.11.001"},{"key":"e_1_2_8_25_1","article-title":"Diagnostic utility of right atrial reservoir strain to identify elevated right atrial pressure in heart failure","author":"Miah N","year":"2020","journal-title":"Int J Cardiol"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.15188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:38:11Z","timestamp":1693211891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.15188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/echo.15188"],"URL":"https:\/\/doi.org\/10.1111\/echo.15188","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"2021-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}