{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T05:01:09Z","timestamp":1748667669609,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Dobutamine stress echocardiography (DSE) is not always feasible in patients with low\u2010gradient severe aortic stenosis (LG\u2010SAS), and there are limited data available on the resting echocardiographic predictors for true\u2010severe aortic stenosis (TSAS). This study investigated resting echocardiographic predictors for TSAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data of 106 LG\u2010SAS patients who underwent DSE were retrospectively analyzed. LG\u2010SAS was defined as an aortic valve area index (AVAi)\u00a0&lt;\u00a0.6\u00a0cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>, and a mean AV pressure gradient\u00a0&lt;\u00a040\u00a0mm Hg. The velocity ratio (VR) was calculated as the peak left ventricular outflow tract velocity\/peak AV velocity. TSAS was defined as a projected AVAi\u00a0&lt;\u00a0.6\u00a0cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 79.3 \u00b1 7.3 years, and 45 (42.5%) were men. The resting AV data were as follows: AVAi, .50 \u00b1 .07 cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>; mean AV pressure gradient, 23.0 \u00b1 7.4\u00a0mm Hg; and VR, .25 \u00b1 .05. The projected AVAi was .58 \u00b1 .09 cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>, and TSAS was documented in 65 (61.3%) patients. In multivariate analysis, the independent predictors of TSAS were AVAi (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.012) and VR (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) with respective best cut\u2010off values of .52\u00a0cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup> and .25 on receiver\u2010operating characteristic curve analysis. According to incremental numbers of the predictors, correct classification percentages of TSAS significantly increased with the Cochran\u2010Armitage trend test (16.2% in no predictors, 65.2% in one predictor, and 95.7 % in two predictors; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Resting AVAi and VR were independent predictors of TSAS in LG\u2010SAS patients. The true severity might be predictable using the combination of resting parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15201","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T20:17:31Z","timestamp":1632428251000},"page":"1731-1740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Resting echocardiographic predictors for true\u2010severe aortic stenosis in patients with low\u2010gradient severe aortic stenosis: A dobutamine stress echocardiography study"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6250-3891","authenticated-orcid":false,"given":"Hirokazu","family":"Onishi","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine St. Marianna University School of Medicine  Kanagawa Japan"},{"name":"Department of Cardiology New Tokyo Hospital  Chiba 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of Cardiology Department of Internal Medicine St. Marianna University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine St. Marianna University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine St. Marianna University School of Medicine  Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine St. Marianna University School of Medicine  Kanagawa 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