{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T07:18:43Z","timestamp":1771658323946,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myocardial injury (MI) can be detected during the acute phase of Coronavirus disease 19 (COVID\u201019) and is associated with a dismal prognosis. Recent imaging studies described the persistence of cardiac abnormalities after the recovery. The aim of the study was to investigate the spectrum of cardiac abnormalities at mid\u2010term follow\u2010up in patients recovered from COVID\u201019 using clinical assessment, laboratory tests, and imaging evaluation with comprehensive echocardiography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is an observational, cross\u2010sectional study assessing an unselected cohort of consecutive patients recovered from COVID\u201019. MI was defined by elevated plasma levels of high sensitive troponin T (hsTnT). At the follow\u2010up, a complete examination including echocardiography was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 123 patients included were divided into two groups according to the presence of MI during hospitalization: group A (without MI) and group B (with MI). After a median of 85 days, group B patients were more frequently symptomatic for dyspnea and had significantly higher values of hsTnT and N\u2010Terminal prohormone of Brain Natriuretic Peptide (NT\u2010proBNP), compared to Group A. No differences between the two groups in left nor right ventricle dimension and ejection fraction were found. However, in group B a significant reduction of mean left ventricle global longitudinal strain was observed (\u201015.7\u00b1.7\u00a0vs \u201018.1\u00b1 .3 in group A, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), together with higher frequency of impaired diastolic function and higher values of pulmonary pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients recovered from COVID\u201019, echocardiography with speckle\u2010tracking analysis may be an useful imaging tool to identify subclinical myocardial dysfunction and potentially guide management strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15215","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T14:50:22Z","timestamp":1634827822000},"page":"1778-1786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Subclinical myocardial dysfunction in patients recovered from COVID\u201019"],"prefix":"10.1111","volume":"38","author":[{"given":"Leonardo","family":"Italia","sequence":"first","affiliation":[{"name":"Cardiovascular Imaging Unit San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo","family":"Ingallina","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Unit San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Napolano","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Unit San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Boccellino","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Unit San Raffaele Scientific Institute  Milan 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Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Esposito","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Experimental Imaging Center Radiology Department San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ciceri","sequence":"additional","affiliation":[{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"},{"name":"Hematology and Bone Marrow Transplantation Unit San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Castagna","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia 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