{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:27Z","timestamp":1787014107050,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In aortic stenosis (AS), chronic pressure overload on left ventricle (LV) leads to LV hypertrophy, impaired relaxation, increased chamber stiffness, fibrosis and left atrial (LA) dilatation. An enlarged LA may be a marker of longstanding diastolic dysfunction (DD) and more advanced disease in AS. We aimed to assess the impact of LA volume index (LAVI) on events in patients with moderate or severe AS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 324 patients (mean age 69\u00a0\u00b1\u00a013 years, 61% men) were included. LA volume was measured by biplane Simpson's method using apical four\u2010 and two\u2010chamber views and indexed to body surface area. An increased LAVI was defined as\u00a0&gt;\u00a034\u00a0ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean EF was 64\u00a0\u00b1\u00a08%, LAVI 35\u00a0\u00b1\u00a014\u00a0ml\/m\n                      <jats:sup>2<\/jats:sup>\n                      and flow rate 244\u00a0\u00b1\u00a070\u00a0ml\/s. The number of total events was 275 (85%): 243 (75%) aortic valve replacement and 32 (10%) deaths. Mean follow\u2010up 23.7\u00a0\u00b1\u00a023.8 months (median 15.2 months). An increased LAVI (45% [\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0145]) was associated with adverse events (HR 1.86; 95% CI 1.24\u20132.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) independent of age, smoking, diabetes, atrial fibrillation, LV ejection fraction, LV mass, aortic valve area, and low flow rate (&lt;200\u00a0ml\/s). In the same multivariate model, when increased LAVI was replaced by E\/e\u2032 ratio \u226514\u00a0cm, no association was found between E\/e\u2019 ratio \u226514\u00a0cm and adverse events (HR 1.18; 95% CI .78\u20131.78,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.430).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LAVI was an independent predictor of adverse events in patients with moderate or severe AS and preserved ejection fraction. Including LAVI in the risk assessment of AS patients may further improve risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.15225","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T02:11:16Z","timestamp":1635473476000},"page":"1893-1899","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Left atrial volume index predicts adverse events in asymptomatic moderate or severe aortic stenosis"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-5019","authenticated-orcid":false,"given":"Sahrai","family":"Saeed","sequence":"first","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital  Bergen Norway"},{"name":"Cardiothoracic Centre Guy's &amp; St Thomas' Hospital  London 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