{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:59:46Z","timestamp":1747184386644,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 59 patients with normal fetal heart structure, blood flow, and heart rhythm (fetal abnormality\u2010negative group) and 50 patients with abnormal fetal heart structure, blood flow, and\/or heart rhythm (fetal abnormality\u2010positive group). Automated Cardiac Motion Quantification (aCMQ) was performed in both groups to obtain left and right ventricular endocardial global longitudinal strain (GLSendo), mid\u2010myocardial global longitudinal strain (GLSmid), and epicardial global longitudinal strain (GLSepi). Parameters between the two groups were compared and correlation analyses performed. A deformation analysis was performed by two trained observers, and reproducibility was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fetal left ventricular and right ventricular global longitudinal strain (LV\u2010GLS and RV\u2010GLS, respectively) decreased in a gradient from the endocardium to the epicardium. LV\u2010GLS and RV\u2010GLS of all myocardial layers were lower in the fetal abnormality\u2010positive than \u2010negative group (all <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). Correlation analysis showed that neither LV\u2010GLS nor RV\u2010GLS was significantly correlated with gestational age in the fetal abnormality\u2010negative group (all <jats:italic>P\u00a0<\/jats:italic>&gt;\u00a00.05), whereas left ventricular GLSendo, GLSmid, and GLSepi were negatively correlated with gestational age in the fetal abnormality\u2010positive group (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.39 to \u2212.44, all <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). Repeatability testing showed that the inter\u2010observer and intra\u2010observer intra\u2010class correlation coefficients for LV\u2010GLS and RV\u2010GLS in each myocardial layer were\u00a0&gt;.75 (all <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As a new speckle tracking echocardiography tool, aCMQ has feasibility and repeatability in evaluating myocardial deformation of the fetal ventricle. This technique might provide helpful information on ventricular myocardial deformation in fetal hearts with abnormal structure or rhythm for clinical guidance in pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15240","type":"journal-article","created":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T07:53:27Z","timestamp":1636530807000},"page":"1924-1931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative evaluation of fetal ventricular function by speckle tracking echocardiography"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-6586","authenticated-orcid":false,"given":"Ling","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Ultrasonic Medicine West China Second University Hospital of Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu Sichuan China"},{"name":"Department of Pediatrics West China Second University Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu Sichuan China"},{"name":"Department of Obstetrics West China Second University Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu Sichuan China"},{"name":"Department of Radiology West China Second University Hospital of Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine West China Second University Hospital of Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine West China Second University Hospital of Sichuan University  Chengdu Sichuan China"},{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) 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