{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T21:37:21Z","timestamp":1787693841997,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The severity of MI declined markedly in the last decade, and contemporary patterns of cardiac remodeling after MI are not defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled community patients with first MI and performed comprehensive two\u2010 and three\u2010dimensional echocardiography. Remodeling was defined as left ventricular (LV) end\u2010systolic volume index (ESVI) above American Society of Echocardiography normal values. Remodeling patterns were characterized as an increase in LVESVI or LV end\u2010diastolic volume index (LVEDVI), or both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2014 and 2016, 213 patients (63\u00b113 years; 34% women) were enrolled within 3 days after MI (77% non\u2010ST\u2010elevation MI). Acute remodeling was present in 51% of patients. Higher troponin and wall motion score index were associated with greater remodeling (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Atrial annular area, leaflet tenting and papillary muscle areas increased with greater remodeling (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). The greater the cardiac remodeling, the lower the LV ejection fraction and global longitudinal strain (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). This decrease in LV function was accompanied by stroke volume augmentation and maintenance of cardiac index at the expense of increased LVEDVI. Different remodeling patterns were identified. Cases showing increased LVEDVI and normal LVESVI had smallest infarct size and better hemodynamics compared to cases with augmented LVESVI and normal LVEDVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acute remodeling occurs in more than half of first MI cases and exhibits different patterns defined by cavity size and hemodynamic profile. Acute remodeling is a global phenomenon, which also involves the left atrium and the mitral apparatus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15245","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T16:10:53Z","timestamp":1638288653000},"page":"2032-2042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cardiac remodeling in acute myocardial infarction: Prospective insights from multimodality ultrasound imaging"],"prefix":"10.1111","volume":"38","author":[{"given":"Sergio","family":"Barros\u2010Gomes","sequence":"first","affiliation":[{"name":"Heart Institute University of S\u00e3o Paulo, S\u00e3o Paulo  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-7865","authenticated-orcid":false,"given":"V\u00e9ronique L.","family":"Roger","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Medicine Mayo Clinic College of Medicine  Rochester Minnesota USA"},{"name":"Epidemiology and Community Health Branch National Heart Lung and Blood Institute National Institutes of Health, Maryland  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin V.","family":"Pislaru","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Medicine Mayo Clinic College of Medicine  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Miyazaki Medical Association Hospital, Miyazaki  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pislaru","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases Medicine Mayo Clinic College of Medicine  Rochester Minnesota 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