{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T19:46:09Z","timestamp":1744400769029},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ratio of early diastolic mitral inflow velocity (E) to early diastolic mitral annular tissue velocity (e\u2019), or E\/e\u2019, is an echocardiographic measure of left ventricular filling pressure. Peri\u2010operative changes in E\/e\u2019 and association with outcomes have been demonstrated in adults undergoing surgery for aortic stenosis (AS). We sought to explore changes in E\/e\u2019 and other diastolic indices in the setting of congenital AS surgery and to assess for association with post\u2010operative outcomes among children and young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective, single\u2010center study was performed among patients 6 months to 30 years of age who underwent congenital AS surgery from 2006 to 2018. Tissue Doppler indices were collected from pre\u2010 and post\u2010operative echocardiograms. Post\u2010operative outcomes were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010six subjects with subvalvar (45%), valvar (47%), and supravalvar (8%) AS underwent surgery at a median age of 9.5 years (IQR: 4.0\u201314.8). Pre\u2010operatively, the lateral E\/e\u2019 ratio was 8.6 (6.7\u201311.0); 33% had E\/e\u2019\u226510. Post\u2010operatively, the lateral e\u2019 decreased to 9.9\u00a0cm\/s (8.0\u201311.4), the E\/e\u2019 ratio increased to 10.4 (8.3\u201313.1); and 53% had E\/e\u2019\u226510 (<jats:italic>p<\/jats:italic>\u2010values\u00a0&lt;\u00a00.0001, 0.0072, and\u00a0&lt;\u00a00.001, respectively). Pre\u2010operative lateral e\u2019 correlated modestly with duration of intubation (\u03c1\u00a0=\u00a0\u22120.24, <jats:italic>p<\/jats:italic>\u2010value 0.048) and post\u2010operative lateral e\u2019 correlated modestly with duration of intubation and length of hospital stay (\u03c1\u00a0=\u00a0\u22120.28 and \u22120.26, <jats:italic>p<\/jats:italic>\u2010values\u00a0=\u00a00.02 and 0.04, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Children and young adults who underwent congenital AS surgery had echocardiographic evidence of diastolic dysfunction pre\u2010operatively that worsened post\u2010operatively. Lateral e\u2019 may be a sensitive indicator of impaired ventricular relaxation in these patients and may impact duration of intubation and hospital stay.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15274","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T13:10:31Z","timestamp":1641906631000},"page":"178-184","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Peri\u2010operative changes in diastolic function and outcomes in congenital aortic valve surgery"],"prefix":"10.1111","volume":"39","author":[{"given":"Meredith","family":"Pesce","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Morgan Stanley Children's Hospital of NewYork Presbyterian\/Columbia University Irving Medical Center  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"LaPar","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Cardiac, Thoracic, and Vascular Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kalfa","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Cardiac, Thoracic, and Vascular Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emile","family":"Bacha","sequence":"additional","affiliation":[{"name":"Department of Surgery Division of Cardiac, Thoracic, and Vascular Surgery  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Freud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Cardiology Morgan Stanley Children's Hospital of NewYork Presbyterian\/Columbia University Irving Medical 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