{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:59:56Z","timestamp":1747184396687,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute right ventricular (RV) failure is common in patients hospitalized with COVID\u201019. Compared to the conventional echocardiographic parameters, right ventricular longitudinal strain (RVLS) is more sensitive and accurate for the diagnosis of RV systolic dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our purpose was to investigate the sustained RV dysfunction echo\u2010quantified by RVLS in patients recovered from severe COVID\u201019. Furthermore, we aimed to assess whether disseminated intravascular coagulation (DIC) has a key role to predict the impaired RV strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of 198 consecutive COVID\u201019 patients hospitalized from March 1, 2020, to April 15, 2020, 45 selected patients who survived from severe COVID\u201019 were enrolled in the study and referred to our echo\u2010lab for transthoracic echocardiography 6\u2010months after discharge. RVLS was calculated as the mean of the strain values of RV free wall. DIC was defined with a validated scoring system: DIC score equal to or more than 5 is compatible with overt\u2010DIC. Categories of acute respiratory distress syndrome (ARDS) were defined based on PaO<jats:sub>2<\/jats:sub>\/FiO<jats:sub>2<\/jats:sub> ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total 26 of 45 patients showed impaired RVLS at 6\u2010months\u2019 follow\u2010up. DIC score was significantly higher in patients with worse RVLS than in those with better RVLS (4.8 \u00b1 .5 vs. 3.6 \u00b1 .6, <jats:italic>p<\/jats:italic> =.03). Stages of ARDS did not modulate this relationship. Finally, overt\u2010DIC results the only independent predictor of sustained RV dysfunction (OR 1.233, 95% CI 1.041\u20131.934, <jats:italic>p<\/jats:italic> =.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sustained RV impairment frequently occurs in patients recovered from severe COVID\u201019. DIC plays a key role, resulting in an independent predictor of sustained RV dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15332","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T02:18:22Z","timestamp":1647051502000},"page":"584-591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sustained right ventricular dysfunction in severe COVID\u201019: The role of disseminated intravascular coagulation"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9119-4311","authenticated-orcid":false,"given":"Alessandro","family":"Malagoli","sequence":"first","affiliation":[{"name":"Division of Cardiology Nephro\u2010Cardiovascular Department Baggiovara Hospital University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiology \u201cGuglielmo da Saliceto\u201d Hospital  Piacenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Zanni","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiology \u201cGuglielmo da Saliceto\u201d Hospital  Piacenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Muto","sequence":"additional","affiliation":[{"name":"Division of Cardiology Nephro\u2010Cardiovascular Department Policlinico University Hospital of Modena University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Tosetti","sequence":"additional","affiliation":[{"name":"Division of Cardiology Nephro\u2010Cardiovascular Department Policlinico University Hospital of Modena University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Tondi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Nephro\u2010Cardiovascular Department Baggiovara Hospital University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1016\/S1473-3099(20)30120-1"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.1001\/jama.2020.1585"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1002\/jmv.26147"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1161\/CIRCULATIONAHA.120.047971"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1016\/j.jacc.2020.08.066"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1093\/ehjci\/jeaa178"},{"doi-asserted-by":"publisher","key":"e_1_2_9_8_1","DOI":"10.1001\/jamacardio.2020.3557"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1016\/j.jcmg.2020.05.004"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1016\/j.echo.2017.06.016"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1016\/j.jcmg.2020.04.014"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1007\/s11239-020-02134-3"},{"doi-asserted-by":"publisher","key":"e_1_2_9_13_1","DOI":"10.1016\/S2352-3026(20)30145-9"},{"unstructured":"WHO.Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance. 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