{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:25:45Z","timestamp":1767374745577,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Predictors for post\u2010operative reverse remodeling in patients with severe aortic regurgitation (AR) and reduced left ventricular ejection fraction (LVEF) are unknown. We performed low\u2010dose dobutamine stress echocardiography (DSE) in patients with severe AR and reduced LVEF to evaluate the relationship between contractile reserve (CR) and reverse remodeling after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In 31 patients with chronic severe AR and reduced LVEF (LVEF\u00a0&lt;\u00a050%), we performed pre\u2010operative DSE, assessed CR, and examined whether changes in preoperative DSE were associated with improvement of post\u2010operative LVEF after aortic valve surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pre\u2010operative echocardiographic findings were as follows: left ventricular (LV) end\u2010diastolic dimension: 67 \u00b1 10\u00a0mm, LV end\u2010systolic dimension: 52 \u00b1 13\u00a0mm, and LVEF: 42 \u00b1 8%. All patients underwent aortic valve surgery. Patients with pre\u2010operative LVEF of \u226545% exhibited a significant increase in LVEF; however, patients with pre\u2010operative LVEF of &lt;45% showed no significant change. When we examined the results of DSE performed in patients with pre\u2010operative LVEF of &lt;45%, \u0394LVEF of \u22656% (with CR) during DSE was related to an improvement in post\u2010operative LVEF; \u0394LVEF of \u22656% during DSE predicted an improvement in post\u2010operative LVEF, with sensitivity 100%; specificity 78%; and area under curve (AUC) .92.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DSE might be a helpful tool for predicting post\u2010operative reverse remodeling in patients with severe AR and moderately reduced LVEF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15334","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T09:52:05Z","timestamp":1647424325000},"page":"599-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Utility of dobutamine stress echocardiography in aortic valve regurgitation and reduced left ventricular function"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-9337","authenticated-orcid":false,"given":"Chihiro","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-4612","authenticated-orcid":false,"given":"Kotaro","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyomi","family":"Ashihara","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Niinami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Tokyo Women's Medical University  Tokyo 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