{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:34:18Z","timestamp":1781660058432,"version":"3.54.5"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and objectives<\/jats:title><jats:p>Mitral valve (MV) prolapse is highly prevalent in patients with atrial septal defect (ASD). Abnormal left ventricular geometry has been proposed as the main mechanism of MV prolapse in ASD, however, the changes in the morphology of the MV apparatus remain to be clarified. Our aim was to assess the MV geometry in patients with ASD and MV prolapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated 99 patients (73% female, median age 40 years) with ASD who underwent a three\u2010dimensional transesophageal echocardiogram. Three\u2010dimensional analysis of the MV was done using dedicated automated software. Transthoracic echocardiographic parameters were assessed post ASD closure in 28 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MV prolapse was found in 39% of patients. Although smaller left ventricular dimensions and greater interatrial shunt were found in patients with MV prolapse compared with those without prolapse, there was no difference in the subvalvular parameters. MV prolapse was associated with larger mitral anterior\u2010posterior diameter, anterolateral\u2010posteromedial diameter, anterior perimeter, posterior perimeter, total perimeter, and anterior leaflet area (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Mitral regurgitation was more frequent in patients with MV prolapse (80\u00a0vs. 48%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with ASD, the main mechanism of MV prolapse is the presence of an organic primary process of the MV apparatus (excessive anterior mitral leaflet tissue and mitral annular enlargement).<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15371","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T04:54:48Z","timestamp":1653368088000},"page":"827-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mitral valve prolapse in patients with atrial septal defect: A quantitative three\u2010dimensional echocardiographic analysis"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-2008","authenticated-orcid":false,"given":"Xochitl A.","family":"Ortiz\u2010Leon","sequence":"first","affiliation":[{"name":"Laboratory of Echocardiography National Institute of Cardiology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Fritche\u2010Salazar","sequence":"additional","affiliation":[{"name":"Laboratory of Echocardiography National Institute of Cardiology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3749-4281","authenticated-orcid":false,"given":"Edith L.","family":"Posada\u2010Martinez","sequence":"additional","affiliation":[{"name":"Laboratory of Echocardiography National Institute of Cardiology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0336-5593","authenticated-orcid":false,"given":"Hugo","family":"Rodriguez\u2010Zanella","sequence":"additional","affiliation":[{"name":"Laboratory of Echocardiography National Institute of Cardiology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra G.","family":"Venegas\u2010Roman","sequence":"additional","affiliation":[{"name":"Laboratory of Echocardiography National Institute of Cardiology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Ruiz Esparza\u2010Due\u00f1as","sequence":"additional","affiliation":[{"name":"Laboratory of Echocardiography National Institute of Cardiology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissa","family":"Sugeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology North Shore University Hospital  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-6146","authenticated-orcid":false,"given":"Jose A.","family":"Arias\u2010Godinez","sequence":"additional","affiliation":[{"name":"Laboratory of Echocardiography National Institute of Cardiology  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq222"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(05)17869\u20106"},{"issue":"6","key":"e_1_2_11_5_1","first-page":"636","article-title":"Atrial septal defect associated with mitral valve prolapse\u2013prevalence and clinical significance]","volume":"61","author":"Sucho\u0144 E","year":"2004","journal-title":"Przegl 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