{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:07:37Z","timestamp":1788887257903,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiac involvement predicts a poor prognosis in patients with systemic lupus erythematosus (SLE). Two\u2010dimensional speckle\u2010tracking echocardiography (2D\u2010STE) are used to identify subclinical myocardial involvement in various diseases. This study objected to evaluate postsystolic shortening (PSS) and early systolic lengthening (ESL) by 2D\u2010STE for early detection of myocardial involvement in patients with SLE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 121 patients with preserved left ventricular ejection fraction (LVEF) in SLE and 30 healthy controls underwent standard 2D\u2010STE in our study. According to SLE disease activity index (SLEDAI), we divided SLE patients into two groups: the group of inactive disease (SLEDAI \u2264 4) and active disease (SLEDAI \u2265 5). The maximum of postsystolic strain index (PSI<jats:sub>max<\/jats:sub>) and early systolic strain index (ESI<jats:sub>max<\/jats:sub>) were acquired from 17 segments of left ventricular (LV). We also compared the PSI<jats:sub>max<\/jats:sub> and ESI<jats:sub>max<\/jats:sub> of basal, medial, and apical segments between SLE patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with healthy controls and the group of SLEDAI \u2264 4, the group of SLEDAI \u2265 5 had higher PSI<jats:sub>max<\/jats:sub> and ESI<jats:sub>max<\/jats:sub> value of global LV and basal segments. The absolute value of global longitudinal strain (GLS) had no difference between the group of active disease and inactive disease. Multivariate analysis demonstrated that PSS was independently associated with SLEDAI and diabetes mellitus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Detection of PSS and ESL enable to identify LV systolic impairment in SLE patients at an early stage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15442","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T13:44:30Z","timestamp":1662644670000},"page":"1284-1290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Postsystolic shortening and early systolic lengthening for early detection of myocardial involvement in patients with systemic lupus erythematosus"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3089-5258","authenticated-orcid":false,"given":"Minjie","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasonics The First 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