{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T03:13:39Z","timestamp":1785726819417,"version":"3.56.0"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 60\u2010year\u2010old patient, professor of physics, presented in 1999 with sudden\u2010onset vitiligo associated with hyperprolactinemia and a prolactinoma. Fearful of potential surgical complications at the peak of his career, the patient declined surgery and opted for medical management with bromocriptine. The decreasing effectiveness of bromocriptine after 5 years required a switch to cabergoline. After a 15\u2010year\u2010course of cabergoline therapy with a cumulative dose of 572\u00a0mg, echocardiographic monitoring demonstrated aortic and mitral valve thickening and regurgitation. An additional 3 years of cabergoline treatment (cumulative dose: 649\u00a0mg) resulted in worsening valve thickening and regurgitation. It is well\u2010recognized that such valvular changes may occur with high\u2010dose cabergoline treatment. We report a case of mitral and aortic vavulopathy in a patient who was treated with long\u2010term (18 years) low\u2010dosage (.5\u20131\u00a0mg weekly) cabergoline.<\/jats:p><jats:p>cabergoline, echocardiography, valvulopathy<\/jats:p>","DOI":"10.1111\/echo.15506","type":"journal-article","created":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T09:19:07Z","timestamp":1670923147000},"page":"61-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term low\u2010dose cabergoline usage: Another association with cardiac valvulopathy"],"prefix":"10.1111","volume":"40","author":[{"given":"Steven","family":"Tessier","sequence":"first","affiliation":[{"name":"Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke A.","family":"Lipton","sequence":"additional","affiliation":[{"name":"Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad I.","family":"Arastu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine St. Luke's Health Network  Bethlehem Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Curiale","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Luke's University Health Network  Bethlehem Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Pathology St. Luke's University Health Network  Bethlehem Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudip","family":"Nanda","sequence":"additional","affiliation":[{"name":"Department of Cardiology St. Luke's University Health Network  Bethlehem Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054830"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310378027"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360767"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERP\u201018\u20100069"},{"key":"e_1_2_8_6_1","unstructured":"Food and Drug Administration Department of Health and Human Services. Supplement approval revision.2011.www.accessdata.fda.gov\/drugsatfda_docs\/appletter\/2011\/020664s011ltr.pdf"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018\u201001071"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007\u20101403"},{"issue":"6","key":"e_1_2_8_9_1","first-page":"797","article-title":"Severe tricuspid regurgitation in a patient receiving low\u2010dose cabergoline for the treatment of acromegaly","volume":"19","author":"Izgi C","year":"2010","journal-title":"J Heart Valve Dis"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016\u20102224"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa882"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.15506","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:09:41Z","timestamp":1692637781000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.15506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,13]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/echo.15506"],"URL":"https:\/\/doi.org\/10.1111\/echo.15506","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,13]]},"assertion":[{"value":"2022-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}