{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:45:42Z","timestamp":1775778342023,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are relatively few studies investigating cardiac structural and functional abnormalities associated with systemic lupus erythematous (SLE). The long\u2010term prognosis of SLE patients is closely related to the cardiovascular events caused by SLE. Accordingly, it is necessary to assess early myocardial systolic function and synchrony.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Overall, 90 patients with SLE were randomly selected from our outpatient and inpatient clinics and divided according to SLE Disease Activity Index (SLE\u2010DAI\u20102000) scores: group A, stable (scores 0\u20134); group B, mildly active stage (scores 5\u20139); and group C, moderately active stage (scores \u226510). Each group included 30 patients. Further, 30 sex\u2010 and age\u2010matched healthy individuals who were referred for check\u2010ups at the same period were selected as controls (group D). The minimum age for entry into the group was 17\u00a0years old. Autostrain LV and three\u2010dimensional quantitative analysis (3DQA) were applied to obtain left ventricular systolic function parameters, information on strain parameters, and correlations between parameters. Simultaneity parameters measured by Autostrain LV and 3DQA were tested for reproducibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A two\u2010by\u2010two comparison of groups A\u2013C showed that as the disease activity score increased, AP4LS%, AP2LS%, AP3LS%, and the LV mean overall longitudinal strain all gradually decreased, while LV longitudinal strain peak time standard deviation (Tls\u2010SD) gradually increased, with all differences being statistically significant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). In groups A\u2013C compared with controls, Tmsv\u201017\u2010SD, Tmsv\u201017\u2010Dif, Tmsv\u201017\u2010SD%, and Tmsv\u201017\u2010Dif% were all significantly prolonged (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Further, Tls\u2010SD was positively correlated with Tmsv\u201017\u2010SD and Tmsv\u201017\u2010Dif, and there was good agreement between Autostrain and 3DQA for the measurement of left ventricular synchrony indexes, with Tmsv\u201017\u2010Dif having the best repeatability (intraobserver interclass correlation coefficient (ICC)\u00a0=\u00a0.979; interobserver ICC\u00a0=\u00a0.848,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Autostrain LV can accurately detect changes in left ventricular myocardial strain in patients with SLE early in the disease, with simple operation. The 3DQA technique can quantitatively evaluate left ventricular systolic synchronization in patients with SLE, and Autostrain LV synchronization index measurements correlate significantly with 3DQA. Both methods are reproducible, but 3DQA is more sensitive to left ventricular synchronous motion changes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15562","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T16:20:36Z","timestamp":1682958036000},"page":"760-767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Value of Autostrain LV in the study of left ventricular systolic function and synchronization in patients with systemic lupus erythematosus"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-7253","authenticated-orcid":false,"given":"Wanqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Jinzhou Medical University Jinzhou Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Jinzhou Medical University Jinzhou Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0056-8862","authenticated-orcid":false,"given":"Yuhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Jinzhou Medical University Jinzhou Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000001464"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel308"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2013.10.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316671810"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-20-3577"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-318256"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.09.011"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/jcecho.jcecho_118_20","article-title":"Effects of sacubitril\/valsartan treatment on left ventricular myocardial torsion mechanics in patients with heart failure reduced ejection fraction 2D speckle tracking echocardiography","volume":"31","author":"Elshafey WEH","year":"2021","journal-title":"J Cardiovasc Echogr"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev309"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318202f701"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.09.017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2478\/rir-2020-0009"},{"key":"e_1_2_9_14_1","first-page":"54","article-title":"Anti\u2010N\u2010methyl\u2010D\u2010aspartate receptor antibodies are associated with fibromyalgia in patients with systemic lupus erythematosus: a case\u2010control study","volume":"35","author":"Park DJ","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4148"},{"key":"e_1_2_9_16_1","first-page":"535","article-title":"Cardiovascular complications in paediatric\u2010onset systemic lupus erythematosus in Saudi Arabian patients","volume":"35","author":"Azhar AS","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.03.014"},{"key":"e_1_2_9_18_1","first-page":"2","article-title":"Non\u2010invasive imaging for congenital heart disease: recent innovations in transthoracic echocardiography","author":"Koestenberger M","year":"2012","journal-title":"J Clin Exp Cardiolog"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-18-S1-W25"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2012.12.002"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.12.021"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.12.012"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002761"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.11.012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13730-012-0031-4"},{"key":"e_1_2_9_26_1","first-page":"256","article-title":"Evaluation of left ventricular mechanical dyssynchrony in patients with heart failure after myocardial infarction by real\u2010time three\u2010dimensional echocardiography","volume":"33","author":"Zhou Q","year":"2012","journal-title":"Saudi Med J"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0889-4"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1352-7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2019.1670810"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090043"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/09612033211027928"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-019-00229-3"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15562","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T14:57:59Z","timestamp":1729349879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.15562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/echo.15562"],"URL":"https:\/\/doi.org\/10.1111\/echo.15562","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}