{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:59:19Z","timestamp":1791345559573,"version":"4.3.1"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Speckle\u2010tracking\u2010derived strains in cardiac chambers may provide better solutions for transthyretin amyloid cardiomyopathy (ATTR\u2010CM) screening. This study aimed to evaluate the efficacy of biventricular strain measurements using speckle tracking for screening <jats:sup>99m<\/jats:sup>Tc\u2010pyrophosphate (<jats:sup>99m<\/jats:sup>Tc\u2010PYP) scintigraphy\u2010positive cardiomyopathy, which is nearly equivalent to ATTR\u2010CM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of transthoracic echocardiographic studies using vendor\u2010independent speckle tracking analysis in older patients (\u226565 years) who underwent <jats:sup>99m<\/jats:sup>Tc\u2010PYP scintigraphy to evaluate the etiology of suspected ATTR\u2010CM in our institute between January 2019 and December 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The entire cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a089) was divided into two subgroups positive <jats:sup>99m<\/jats:sup>Tc\u2010PYP scan results (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) and negative <jats:sup>99m<\/jats:sup>Tc\u2010PYP scan results (<jats:italic>n<\/jats:italic>\u00a0=\u00a055). In the multivariate analysis, posterior wall thickness (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003, odds ratio [OR]:1.48, 95% confidence interval [CI]:1.14 \u20131.92), left ventricular longitudinal strain apical\/basal ratio (LVLSapi\/bas) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.015, OR: 2.78, 95% CI: 1.23\u20136.32, and right ventricular longitudinal strain (RVLS) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003, OR: 1.15, 95% CI: 1.05 \u20131.26) were selected to be the most representative echocardiographic findings in <jats:sup>99m<\/jats:sup>Tc\u2010PYP positive cardiomyopathy. The receiver operating characteristic analysis indicated that posterior wall thickness (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001, area under the curve [AUC]: .821, cut\u2010off value: 14.0\u00a0mm), LVLSapi\/bas (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, AUC: .802, cut\u2010off value: 2,16), and RVLS (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001, AUC: .791, cut\u2010off value: \u201018.7%) could significantly detect <jats:sup>99m<\/jats:sup>Tc\u2010PYP positive results with an excellent credibility. Echocardiographic score points calculated using the summary of these three parameters in each patient revealed that a 2\u2010point score had a fair sensitivity (85%) and an excellent specificity (93%), while a 1\u2010point score had an excellent sensitivity (91%) and a modest specificity (53%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our proposed echocardiographic screening tool for <jats:sup>99m<\/jats:sup>Tc\u2010PYP scintigraphy\u2010positive cardiomyopathy may help clinicians manage patients with suspected ATTR\u2010CM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15626","type":"journal-article","created":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T04:54:07Z","timestamp":1685163247000},"page":"634-641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Echocardiographic score for the screening of cardiac amyloidosis with positive 99m technetium pyrophosphate scintigraphy 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