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The objective of this study was to evaluate the influence of measurement error on the echocardiographic evaluation of the severity of AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A systematic review was performed to examine whether measurement errors are reported in studies focusing on the prognostic value of peak aortic jet velocity (V<jats:sub>max<\/jats:sub>), mean pressure gradient (MPG), and effective orifice area (EOA) in asymptomatic patients with AS. Out of the 37 studies reviewed, 17 (46%) acknowledged the existence of measurement errors, but none of them utilized methods to address them. Secondly, the magnitude of potential errors was collected from available literature for use in clinical simulations. Interobserver variability ranged between 0.9% and 8.3% for V<jats:sub>max<\/jats:sub> and MPG but was higher for EOA (range 7.7%\u201012.7%), indicating lower reliability. Assuming a circular left ventricular outflow tract area led to a median underestimation of EOA by 23% compared to planimetry by other modalities. A clinical simulation resulted in the reclassification of 42% of patients, shifting them from a diagnosis of severe AS to moderate AS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Measurement errors are underreported in studies on echocardiographic assessment of AS severity. These errors can lead to misclassification and misdiagnosis. Clinicians and scientists should be aware of the implications for accurate clinical decision\u2010making and assuring research validity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15664","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T08:24:05Z","timestamp":1690791845000},"page":"892-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Improving accuracy in diagnosing aortic stenosis severity: An in\u2010depth analysis of echocardiographic measurement error through literature review and simulation study"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-4220","authenticated-orcid":false,"given":"Bart J. J.","family":"Velders","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf H. 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