{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T08:53:09Z","timestamp":1770713589782,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>His bundle pacing (HBP) has proved to be a valuable alternative enabling the physiological activation of cardiac contraction in cardiac resynchronization therapy (CRT). At present, however, little is known about the optimal method of programming of the His bundle\u2010paced CRT systems in terms of achieving the best cardiac output.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the impact of cardiac resynchronization therapy with conduction system pacing (CRT+CSP) on echo\u2010based hemodynamic parameters in the early post\u2010operative measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study enrollment criteria included: permanent atrial fibrillation, heart failure and bundle branch block. All patients underwent implantation of CRT + HBP. During the post\u2010operative phase, we aimed to optimize HOT\u2010CRT settings in order to achieve the greatest cardiac output assessed by complex echocardiographic measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 21 patients, mean age 71.2 (6.3) years, predominantly men (71.4%) with non\u2010ischemic cardiomyopathy 62%. All patients had heart failure with NYHA functional class III and IV (81%). Mean left ventricular ejection fraction was 27.5 (9.7%). The mean duration of the QRS complex was 148.8\u00a0ms. The effects of resynchronization pacing: HBP alone, HBP with left ventricular pacing, HBP with biventricular pacing (BiV) and BiV without HBP \u200b\u200bwere analyzed consecutively. HBP combined with left ventricular pacing demonstrated the best hemodynamic response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>His bundle pacing coupled with LV pacing proved to be the most advantageous pacing program setting with regard to cardiac output. Moreover, it performed better than biventricular pacing and significantly better than RV pacing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15679","type":"journal-article","created":{"date-parts":[[2023,8,26]],"date-time":"2023-08-26T06:14:00Z","timestamp":1693030440000},"page":"1068-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The usefulness of echo\u2010based hemodynamic parameters in cardiac resynchronization therapy with conduction system pacing for optimal device programing"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1833-2404","authenticated-orcid":false,"given":"Krzysztof","family":"Boczar","sequence":"first","affiliation":[{"name":"Department of Electrocardiology The John Paul II Hospital  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8331-3210","authenticated-orcid":false,"given":"Andrzej","family":"Z\u0105bek","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology The John Paul II Hospital  Krak\u00f3w Poland"},{"name":"Institute of Cardiology Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8951-2341","authenticated-orcid":false,"given":"Karolina","family":"Goli\u0144ska\u2010Grzyba\u0142a","sequence":"additional","affiliation":[{"name":"Department of Noninvasive Cardiovascular Laboratory John Paul II Hospital  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"S\u0142awuta","sequence":"additional","affiliation":[{"name":"Department of Internal and Occupational Diseases Hypertension and Clinical Oncology Wroclaw Medical University  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"D\u0119bski","sequence":"additional","affiliation":[{"name":"Norwich Medical School University of East Anglia  Norwich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Gajek","sequence":"additional","affiliation":[{"name":"Department of Emergency Medical Service Wroclaw Medical University  Wroclaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Holcman","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Diseases Krakow Jagiellonian University Medical College John Paul II Hospital  Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4545-6514","authenticated-orcid":false,"given":"Andrzej","family":"Gackowski","sequence":"additional","affiliation":[{"name":"Jagiellonian University, Medical College Institute of Cardiology Department of Coronary Disease and Heart Failure John Paul II Hospital  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Lelakowski","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology The John Paul II Hospital  Krak\u00f3w Poland"},{"name":"Institute of Cardiology Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Ma\u0142ecka","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology The John Paul II Hospital  Krak\u00f3w Poland"},{"name":"Institute of Cardiology Jagiellonian University Medical College  Krak\u00f3w 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