{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:00:33Z","timestamp":1747184433276,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to investigate fetal cardiac output (CO) in pregnancies with preterm premature rupture of membranes (PPROM) and its relationship with umbilical cord pH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study in total 90 pregnancies at 24\u201337\u00a0weeks gestation including 42 pregnancies with PPROM and 48 that healthy controls. Fetal cardiac function including combined, left and right CO <jats:italic>z<\/jats:italic>\u2010scores were compared. The neonates in the PPROM group were separated with umbilical cord pH above and below 7.25, and cardiac output was compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In PPROM group, CCO z\u2010score, left cardiac output (LCO) z\u2010score, and right cardiac output (RCO) were significantly lower compared to healthy pregnancies (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.036, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.032, respectively), while RCO <jats:italic>z<\/jats:italic>\u2010score showed no significant differences between the two groups. The aortic annulus and pulmonary artery annulus <jats:italic>z<\/jats:italic>\u2010scores were measured smaller in the PPROM group (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.000 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001, respectively). In PPROM group, the fetal LCO z\u2010score was significantly lower in neonates with an umbilical cord pH of 7.25 or less (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides evidence that fetal CCO is lower in PPROM compared with healthy pregnancies. Reduced LCO z\u2010scores may be useful for predicting adverse neonatal outcomes in pregnancies with PPROM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15689","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:53:00Z","timestamp":1694526780000},"page":"1156-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of fetal cardiac output in preterm premature rupture of membranes"],"prefix":"10.1111","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1283-4032","authenticated-orcid":false,"given":"Merve","family":"Ozturk Agaoglu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Ministry of Health Ankara City Hospital  Cankaya Ankara 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