{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:23Z","timestamp":1753878563534,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T00:00:00Z","timestamp":1702252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009664","name":"Sociedad Espa\u00f1ola de Cardiolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Iron deficiency correction with ferric carboxymaltose improves symptoms and reduces rehospitalization in patients with reduced left ventricular ejection fraction. The mechanisms underlying these improvements are poorly understood. This study aimed to determine changes in left ventricular contractility after iron treatment as reflected in global longitudinal strain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective single\u2010center study including 43 adults with reduced ejection fraction, non\u2010anemic iron deficiency, and functional class II\u2010III heart failure despite optimal medical treatment. Global longitudinal strain through speckle\u2010tracking echocardiography was measured at baseline and 4\u00a0weeks after ferric carboxymaltose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant improvement in global longitudinal strain was detected (from \u221212.3%\u00a0\u00b1\u00a04.0% at baseline to \u221215.6%\u00a0\u00b1\u00a04.1%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001); ferritin and transferrin saturation index had increased, but ejection fraction presented no significant changes (baseline 35.7%\u00a0\u00b1\u00a04.6%, follow\u2010up 37.2%\u00a0\u00b1\u00a06.6%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.073).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with heart failure and reduced ejection fraction, the correction of iron deficiency with ferric carboxymaltose is associated with an early improvement in global longitudinal strain, possibly suggesting a direct effect of iron correction on myocardial contractility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15726","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T18:48:28Z","timestamp":1702320508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early improvement of global longitudinal strain after iron deficiency correction in heart failure with reduced ejection fraction"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-9617","authenticated-orcid":false,"given":"Mario","family":"Sutil\u2010Vega","sequence":"first","affiliation":[{"name":"Cardiology Department Parc Taul\u00ed Hospital Universitari. Institut d'Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT) Universitat Aut\u00f2noma de Barcelona  Sabadell Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Cardiology Department Parc Taul\u00ed Hospital Universitari. Institut d'Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT) Universitat Aut\u00f2noma de Barcelona  Sabadell Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00cdngrid","family":"Colomer\u2010Asenjo","sequence":"additional","affiliation":[{"name":"Cardiology Department Parc Taul\u00ed Hospital Universitari. Institut d'Investigaci\u00f3 i Innovaci\u00f3 Parc Taul\u00ed (I3PT) Universitat Aut\u00f2noma de Barcelona  Sabadell Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadwa","family":"Taibi","sequence":"additional","affiliation":[{"name":"Cardiology Department Parc Taul\u00ed Hospital Universitari. 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