{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:01:55Z","timestamp":1781218915706,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We previously reported a higher left atrial volume index (LAVI) was independently associated with left atrial (LA) appendage (LAA) thrombus formation in 737 patients with non\u2010valvular atrial fibrillation (NVAF) receiving appropriate oral anticoagulation therapy. Since our previous study was a retrospective single\u2010center study, we designed and conducted a prospective multi\u2010center study to verify our findings for LAVI as a predictor of LAA thrombus in patients with NVAF receiving appropriate oral anticoagulation therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective multi\u2010center study comprised 746 consecutive patients with NVAF recruited between December 2021 and March 2023 from eight institutions in Japan, who were receiving appropriate oral anticoagulation therapy, had undergone transthoracic echocardiography and transesophageal echocardiography (TEE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LAA thrombi were observed in 21 patients (2.8%). The prevalence of LAA thrombus formation in patients with paroxysmal AF (PAF) was significantly lower than that in patients with non\u2010PAF (0.7% vs. 4.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.006). LAA thrombus formation was detected in none (0\/171) of the patients with normal size LA (LAVI\u00a0\u2264\u00a034\u00a0mL\/m<jats:sup>2<\/jats:sup>). The prevalence of LAA thrombus formation in patients with mildly dilated LA (LAVI: 34\u201349.9\u00a0mL\/m<jats:sup>2<\/jats:sup>) was 2.1% (6\/283), but that in PAF patients was low at 1.0% (1\/104). Furthermore, this prevalence in patients with severely dilated LA (LAVI \u2265 50\u00a0mL\/m<jats:sup>2<\/jats:sup>) was high at 5.1% (15\/292).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this prospective multi\u2010center study are consistent with those of our previous study. Thus, the need for TEE prior to catheter ablation or electrical cardioversion can be determined by the level of LAVI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15735","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T12:50:57Z","timestamp":1704891057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Left atrial volume index as a predictor for left atrial appendage thrombus in patients with non\u2010valvular atrial fibrillation receiving appropriate oral anticoagulation therapy: A prospective multi\u2010center study"],"prefix":"10.1111","volume":"41","author":[{"given":"Hiroaki","family":"Shiraki","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Tsunamoto","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine  Kobe Japan"},{"name":"Department of Cardiology Hyogo Prefectural Harima\u2010Himeji General Medical Center  Himeji Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuari","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hyogo Prefectural Harima\u2010Himeji General Medical Center  Himeji Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kakogawa Central City Hospital  Kakogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Shimoura","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kakogawa Central City Hospital  Kakogawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Matsuzoe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Yodogawa Christian Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Soga","sequence":"additional","affiliation":[{"name":"Division of Cardiology Osaka Saiseikai Nakatsu Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Imanishi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hyogo Prefectural Awaji Medical Center  Sumoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Yokota","sequence":"additional","affiliation":[{"name":"Division of Cardiology Kobe Red Cross Hospital  Kobe 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