{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:10:08Z","timestamp":1784848208514,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The LV myocardial strain and hemodynamic forces (HDFs) are innovative markers of LV function. Aortic coarctation is safely repaired in infancy; however, mortality and morbidity remain increased in later life. The study investigated the role of left ventricular myocardial deformation and HDFs in asymptomatic patients who underwent successful aortic coarctation repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and echocardiographic data were analyzed from 42 repaired CoA, 32\u00a0\u00b1\u00a020 years after surgery, 2D echocardiographic global longitudinal strain (GLS), circumferential strain (GCS) and HDFs were determined. CoA patients were compared with 42 patients affected by blood hypertension and 84 healthy controls; all matched for age and gender.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All groups had normal LV ejection fraction (LVEF), dimensions, and volumes. CoA patients showed a significantly higher rate of LV mass indexed (<jats:italic>p<\/jats:italic>\u00a0&lt; .001) and left atrial volumes indexed (<jats:italic>p<\/jats:italic>\u00a0&lt; .001). LV myocardial and endocardial global longitudinal and circumferential strain were decreased in CoA patients (<jats:italic>p<\/jats:italic>\u00a0&lt; .001, <jats:italic>p<\/jats:italic>\u00a0&lt; .001; <jats:italic>p<\/jats:italic>\u00a0= .032 and <jats:italic>p<\/jats:italic>\u00a0&lt; .001, respectively). HDF parameters such as LV longitudinal force, LV systolic longitudinal force and LV impulse (LVim) were uniformly reduced (<jats:italic>p<\/jats:italic>\u00a0= .006, <jats:italic>p<\/jats:italic>\u00a0= .001, and <jats:italic>p<\/jats:italic>\u00a0= .001, respectively). LV myocardial strain and HDF parameter values were independently associated with hospitalization for heart failure on univariable Cox regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite preserved LVEF, patients with CoA had lower LV myocardial strain and HDF parameters values, independently associated with hospitalization for heart failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15742","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T06:14:50Z","timestamp":1706076890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of left ventricular hemodynamic forces in adult patients with treated aortic coarctation and preserved left ventricular systolic function"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-7482","authenticated-orcid":false,"given":"Giorgio","family":"Faganello","sequence":"first","affiliation":[{"name":"Cardiovascular Center University Hospital and Health Services of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Collia","sequence":"additional","affiliation":[{"name":"Department of Engineering and Architecture University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Pagura","sequence":"additional","affiliation":[{"name":"Cardiovascular Center University Hospital and Health Services of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Croatto","sequence":"additional","affiliation":[{"name":"Cardiovascular Center University Hospital and Health Services of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia Maria","family":"Tosoni","sequence":"additional","affiliation":[{"name":"Cardiovascular Center University Hospital and Health Services of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Toritto","sequence":"additional","affiliation":[{"name":"Cardiovascular Center University Hospital and Health Services of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Pedrizzetti","sequence":"additional","affiliation":[{"name":"Department of Engineering and Architecture University of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Di","family":"Lenarda","sequence":"additional","affiliation":[{"name":"Cardiovascular Center University Hospital and Health Services of Trieste  Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.1029"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(19)30402-X"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa554"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.016"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17515"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.05.075"},{"issue":"15","key":"e_1_2_11_8_1","first-page":"1190","article-title":"Long\u2010term mortality and cardiovascular burden for adult survivors of coarctation of the aorta","volume":"105","author":"Lee MG","year":"2019","journal-title":"Heart"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2020.01.016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.121.013383"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.694"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-016-0838-8"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.03.019"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.08.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-020-01934-1"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-022-02756-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90771-X"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.5.1077"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02239541"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu184"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2017.06.046"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey102"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.02.027"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023199"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009672"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.084"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2022.100130"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08763"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-018-0126-y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.12.012"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.05.033"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.192997"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.847772"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.612"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.023417"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12031218"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12310"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.122.014415"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T12:26:51Z","timestamp":1712752011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.15742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/echo.15742"],"URL":"https:\/\/doi.org\/10.1111\/echo.15742","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15742"}}