{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:48Z","timestamp":1753878648624,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the predictive ability of global longitudinal strain (GLS) and mechanical dispersion for coronary stenosis and provide a more reliable noninvasive method for diagnosis of obstructive coronary artery disease(OCAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven patients diagnosed with suspected CAD were included in the study. Patients with coronary stenosis greater than 50% were assigned as OCAD, while the others were assigned as non obstructive coronary artery disease(NOCAD). General information was collected and patients underwent speckle tracking echocardiogram(STE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Spearman's correlation analysis showed that GLS and mechanical dispersion were positively correlated with the degree of coronary stenosis (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.383, 0.342, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05), and there was also a positive correlation between GLS and mechanical dispersion (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.327, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). GLS, longitudinal strain (LS) of each chamber, and mechanical dispersion were higher in the OCAD group than in the NOCAD group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Univariate regression analysis showed that GLS, each lumen LS and mechanical dispersion were statistically significant (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Multifactorial regression analysis showed that elevated GLS (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) and elevated mechanical dispersion (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.030) were independent risk factors for OCAD. The ROC curves showed that GLS predicted OCAD (AUC area 0.745, 95% CI 0.624 to 0.865) versus mechanical discrete prediction of OCAD (AUC area 0.702, 95% CI 0.569 to 0.834) were more diagnostic than conventional cardiac ultrasound observations of ventricular wall motion abnormalities (AUC area 0.566, 95% CI 0.463 to 0.669).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combining GLS with mechanical dispersion can rapidly assess OCAD in a very short period, which has strong promotion value and in\u2010depth research value.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15744","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T09:05:57Z","timestamp":1705482357000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical study of two\u2010dimensional speckle tracking to evaluate abnormal myocardial motion due to coronary lesions"],"prefix":"10.1111","volume":"41","author":[{"given":"Lin","family":"Sun","sequence":"first","affiliation":[{"name":"Departments of Cardiology Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiwei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Departments of Cardiology Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidan","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Cardiology Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[{"name":"Departments of Cardiology Hospital of Harbin Medical University  Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hangzhou Lin'an District Hospital of Traditional Chinese Medicine Hangzhou  Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4738-6828","authenticated-orcid":false,"given":"Jingjie","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Cardiology Hospital of Harbin Medical University  Harbin 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