{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:02:13Z","timestamp":1789131733465,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated filling pressure is a hallmark of heart failure (HF) and portends poor prognosis. Accurate diagnosis is challenging, given that patients with normal filling pressure at rest develop disproportionate elevation with sudden preload increase. We aimed to test the accuracy of the ratio between mitral inflow velocity (E) and left ventricular stroke volume (SV) to identify patients with elevated filling pressure with passive leg lifting (PLL) and compare this with other echocardiographic surrogates of filling pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Doppler echocardiography and right heart catheterization (RHC) were simultaneously performed in 37 patients (11 males, mean age 67\u00a0\u00b1\u00a012 years) with exertional dyspnea. Twenty\u2010six healthy controls (14 males, mean age 60\u00a0\u00b1\u00a012 years) were added as reference. SV, cardiac output (CO), tricuspid regurgitation peak gradient (TRG), mitral E\u2010wave (E)\u00a0and early myocardial velocity (e\u2019) were obtained at rest and with PLL. E\/SV, E\/CO and E\/e\u2019 were calculated and correlated with invasive pulmonary capillary wedge pressures (PCWP) with PLL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During PLL, E\/SV (AUC\u00a0=\u00a00.94) displayed stronger diagnostic ability to identify PCWP\u00a0&gt;15\u00a0mmHg than E\/e\u2019 (AUC\u00a0=\u00a00.81), mitral E\/A ratio (0.76) and resting invasive PCWP (0.84). An E\/SV cutoff of\u00a0&gt;1.0 showed 88% sensitivity and 75% specificity to identify elevated PCWP. Further, 10 patients (27%) were reassigned during PLL from normal to postcapillary pulmonary hypertension (postCPH), and 6 patients (16%) switched diagnosis from precapillary PH (preCPH) to postCPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel E\/SV ratio identifies patients with elevated PCWP with PLL and displays stronger diagnostic performance than routinely utilized echocardiographic measures such as E\/e\u2019 in addition to resting, catheterization derived PCWP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15756","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T07:15:22Z","timestamp":1708758922000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mitral E\u2010wave to stroke volume ratio displays stronger diagnostic performance to identify elevated left ventricular filling pressures than mitral E\/e\u2019 during passive leg lift: A cross\u2010sectional study employing simultaneous echocardiography and catheterization"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0676-0604","authenticated-orcid":false,"given":"Ashwin","family":"Venkateshvaran","sequence":"first","affiliation":[{"name":"Clinical Physiology, Department of Clinical Sciences Lund Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Surgical &amp; and Perioperative sciences Umea, University  Umea Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000533589"},{"issue":"18","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.021165","article-title":"Validation of the 2016 ASE\/EACVI Guideline for diastolic dysfunction in patients with unexplained dyspnea and a preserved left ventricular ejection fraction","volume":"10","author":"Bovenkamp AA","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"4","key":"e_1_2_9_4_1","first-page":"1e","article-title":"Group EESD. [2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension]","volume":"24","author":"Humbert M","year":"2023","journal-title":"G Ital Cardiol (Rome)"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex067"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.06.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew082"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2016.11.005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeac036"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeab154"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz641"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01531-w"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2019.01.037"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2004.08.033"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14161"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.04.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024822"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T10:46:50Z","timestamp":1709117210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.15756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/echo.15756"],"URL":"https:\/\/doi.org\/10.1111\/echo.15756","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15756"}}