{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:20:54Z","timestamp":1753878054465,"version":"3.41.2"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T00:00:00Z","timestamp":1711152000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cardiac contractility modulation (CCM) is a novel device\u2010based therapy used to treat patients with heart failure with reduced ejection fraction (HFrEF). In both randomized clinical trials and real\u2010life studies, CCM has been shown to improve exercise tolerance and quality of life, reverse left ventricular remodeling, and reduce hospitalization in patients with HFrEF. In this case report, we describe for the first time the use of CCM combined with left bundle branch pacing (LBBP) cardiac resynchronization therapy pacemaker (CRT\u2010P) implantation therapy in a female with a 22\u2010year history of non\u2010ischemic dilated cardiomyopathy. With the optimal medical therapy and cardiac resynchronization therapy (CRT) strategies, the patient's quality of life initially recovered to some extent, but began to deteriorate in the past year. Additionally, heart transplantation was not considered due to economic reasons and late stage systolic heart failure. This is the first case of CCM implantation in Fujian Province and the first report of a combined CCM and left bundle branch pacing CRT\u2010P implantation strategy in a patient with non\u2010ischemic etiology dilated cardiomyopathy in China.<\/jats:p>","DOI":"10.1111\/echo.15762","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T09:54:50Z","timestamp":1711187690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Use of cardiac contractility modulation combined with left bundle branch pacing CRT\u2010P in a female with a 22\u2010year history of non\u2010ischemic dilated cardiomyopathy: A case report"],"prefix":"10.1111","volume":"41","author":[{"given":"Lili","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine The First Affiliated Hospital of Xiamen University  Xiamen China"},{"name":"The School of Clinical Medicine Fujian Medical University  Xiamen China"},{"name":"Xiamen Key Laboratory of Genetic Testing  Xiamen China"},{"name":"School of Public Health Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiao","family":"Ma","sequence":"additional","affiliation":[{"name":"The School of Clinical Medicine Fujian Medical University  Xiamen China"},{"name":"Department of Cardiology The First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueming","family":"Wu","sequence":"additional","affiliation":[{"name":"The School of Clinical Medicine Fujian Medical University  Xiamen China"},{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ge","sequence":"additional","affiliation":[{"name":"The School of Clinical Medicine Fujian Medical University  Xiamen China"},{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianming","family":"Liang","sequence":"additional","affiliation":[{"name":"Center of Clinical Laboratory, Zhongshan Hospital School of Medicine, Xiamen University  Xiamen China"},{"name":"Institute of Infectious Disease School of Medicine Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1645-8871","authenticated-orcid":false,"given":"Rong","family":"Tang","sequence":"additional","affiliation":[{"name":"The School of Clinical Medicine Fujian Medical University  Xiamen China"},{"name":"Department of Cardiology The First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31071-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10262"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.08.022"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.6.730"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013474"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043399"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032423"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.592"},{"key":"e_1_2_8_11_1","unstructured":"KuschykJ N\u00e4geleH Heinz\u2010KuckK et\u00a0al Cardiac contractility modulation treatment in patients with symptomatic heart failure despite optimal medical therapy and cardiac resynchronization therapy (CRT). 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