{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T10:38:05Z","timestamp":1793702285569,"version":"4.5.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mixed pulmonary disease with pulmonary regurgitation (PR) and stenosis (PS) in repaired tetralogy of Fallot (rTOF) can negatively impact ventricular health. Myocardial strain has been shown to be more sensitive at detecting occult ventricular dysfunction compared to right ventricular ejection fraction (RV EF). We hypothesize that rTOF patients with predominant PS will have lower RV global longitudinal strain (RV GLS) prior to and post\u2010transcatheter pulmonary valve replacement (TPVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort of rTOF patients who underwent cardiac magnetic resonance (CMR) and cardiac catheterization for right ventricular pressure (RVSP) measurement were analyzed at three time points: before valve implantation, at discharge and within 18 months post\u2010TPVR. Patients were dichotomized into three groups based on RVSP: 0%\u201349%, 50%\u201374%, and &gt;75%. RV GLS and left ventricular (LV) GLS by speckle tracking echocardiography (STE) were obtained from the apical 4\u2010chamber using TomTec software (TOMTEC IS, Germany).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight patients were included. Every 14.3% increase in preimplantation RVSP above 28% was associated with an absolute magnitude 1% lower RV GLS (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Preimplantation RVSP when 75% or higher had 3.36% worse RV GLS than the lowest bin (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.014). Overall, average RV strain magnitude was higher when preimplantation RVSP was less than 50% and had greater improvement over the three time points. Higher post implantation RVSP correlated with lower strain magnitude.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with significant PS (&gt;50%) may benefit from earlier PVR and not depend solely on RV size and EF. Myocardial strain may be a more sensitive marker of function; however, larger, prospective studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15765","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T06:33:30Z","timestamp":1707287610000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of pulmonary stenosis on right ventricular global longitudinal strain in repaired tetralogy of Fallot patients post transcatheter pulmonary valve replacement"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4165-6463","authenticated-orcid":false,"given":"Jason L.","family":"Williams","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Duke University Medical Center  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4462-3114","authenticated-orcid":false,"given":"Anudeep K.","family":"Dodeja","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Connecticut Children's Hospital  Hartford Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-995X","authenticated-orcid":false,"given":"Brian","family":"Boe","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Joe DiMaggio Children's Hospital Heart Institute  Hollywood Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-0651","authenticated-orcid":false,"given":"Stefani","family":"Samples","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Ann and Robert H. 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