{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:30:05Z","timestamp":1753878605495,"version":"3.41.2"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Our goal was to use three dimensional (3D) strain analysis to evaluate myocardial function and ascending aorta elasticity changes in juvenile dermatomyositis (JDM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2019 and 2021, 23 JDM patients and 20 healthy volunteers participated. Both groups underwent 2D and 3D strain analysis, assessing aortic stiffness using aortic distensibility, stiffness index, strain, and elastic modulus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>JDM patients had a median age of 13.3\u00a0\u00b1\u00a05.2 years, while controls had a median age of 13.8\u00a0\u00b1\u00a04.76 years. 3D strain analysis revealed significantly lower global longitudinal (GLS) and circumferential strain (GCS) in JDM patients compared to controls. Specifically, 3D GLS was notably reduced in patients (\u221228.1% vs. \u221231%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.047) compared to controls, and 3D GCS was also lower in patients (\u221227.5% vs. \u221230.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.019) compared to controls. Aortic strain and elastic modulus were significantly lower in JDM patients, while aortic stiffness index and distensibility showed no significant differences. Correlation analyses within the JDM group revealed a negative correlation between 3D GLS and age at diagnosis (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.561, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04), as well as a positive correlation between 3D GLS and both aortic strain (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.514, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.0001) and elastic modulus (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.320, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) in JDM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated a trend towards lower ejection fraction and strain in patients with JDM, along with increased aortic stiffness using 3D echocardiography. These findings suggest potential cardiovascular involvement in juvenile dermatomyositis, emphasizing the importance of comprehensive cardiac assessments in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15776","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T12:09:10Z","timestamp":1707912550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring cardiovascular implications of juvenile dermatomyositis: Insights from aortic stiffness analysis and 3D echocardiography"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5600-7899","authenticated-orcid":false,"given":"Reyhan","family":"Dedeoglu","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology \u0130stanbul University\u2010Cerrahpa\u015fa Medical School Istanbul 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