{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:29Z","timestamp":1787014109272,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Chronic thromboembolic pulmonary disease (CTEPD) can lead to exercise limitations even without right ventricular (RV) dysfunction or pulmonary hypertension at rest. Combining exercise stress echocardiography with cardiopulmonary exercise testing (ESE\u2010CPET) for RV function and pressure changes combined measuring overall function may be useful for CTEPD evaluation. This study aims to investigate CPET and ESE results to elucidate the mechanisms of exercise limitation in mild CTEPD cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among our CTEPD registry, 50 patients who performed both right heart catheterization data of mild disease (less than 30\u00a0mm Hg of mean pulmonary arterial pressure (mPAP)) and ESE\u2010CPET were enrolled.\u00a0Echocardiography and CPET\u2010derived parameters were compared with hemodynamic parameters measured through right heart catheterization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Peak VO\n                      <jats:sub>2<\/jats:sub>\n                      (maximal oxygen consumption) was decreased in overall population (71.3\u00a0\u00b1\u00a016.3% of predictive value). Peak VO\n                      <jats:sub>2<\/jats:sub>\n                      during exercise was negatively correlate with mPAP and pulmonary vascular resistance at rest. A substantial increase in RV systolic pressure (RVSP) was observed during exercise (RVSP: pre\u2010exercise 37.2\u00a0\u00b1\u00a011.8\u00a0mm Hg, postexercise 64.3\u00a0\u00b1\u00a024.9\u00a0mm Hg,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0&lt;\u00a0.001). Furthermore, RV function deteriorated during exercise when compared to the baseline (RV fractional area change: 31.5\u00a0\u00b1\u00a010.0% to 37.8\u00a0\u00b1\u00a07.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0&lt;\u00a0.001; RV global longitudinal strain: \u221217.1\u00a0\u00b1\u00a04.2% to \u221217.7\u00a0\u00b1\u00a03.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u00a0&lt;\u00a0.001) even though basal RV function was normal. While an excessive increase in RVSP during exercise was noticed in both groups, dilated RV and RV dysfunction during exercise were demonstrated only in the impaired exercise capacity group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CTEPD patients with mild PH or without PH exhibited limited exercise capacity alongside an excessive increase in RVSP during exercise. Importantly, RV dysfunction during exercise was significantly associated with exercise capacity. ESE\u2010CPET could aid in comprehending the primary cause of exercise limitation in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.15795","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T06:54:06Z","timestamp":1710917646000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Usefulness of cardiopulmonary exercise test combined with exercise stress echocardiography in mild chronic thromboembolic pulmonary disease"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7693-4657","authenticated-orcid":false,"given":"Min Sun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"},{"name":"Division of Cardiology Department of Medicine Biomedical Research Institute Pusan National University Hospital Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kina","family":"Jeon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taek Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Yun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hoon","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Pulmonary Hypertension Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Ji","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Chol","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk\u2010Kyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"},{"name":"Division of Cardiology, Department of Internal Medicine Samsung Changwon Hospital, Sungkyunkwan University School of Medicine  Changwon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010A","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Heart Vascular Stroke Imaging Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"},{"name":"Division of Cardiology Department of Medicine Pulmonary Hypertension Center Heart Vascular Stroke Institute Samsung Medical Center Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02828-2020"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.07.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/18.suppl_D.2"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jer021"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2005.12.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jen175"},{"key":"e_1_2_9_9_1","first-page":"S84","volume-title":"Cardiopulmonary exercise testing in pulmonary hypertension","author":"Weatherald 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