{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:32Z","timestamp":1753878572128,"version":"3.41.2"},"reference-count":3,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Loeys\u2010Dietz syndrome (LDS) is an autosomal\u2010dominant connective tissue disorder associated with mutations in the transforming growth factor \u03b2 receptor. It is characterized by distinctive craniofacial changes, skeletal features, and cardiovascular complications. We present a case of a 24\u2010year\u2010old male with development delay and a one\u2010year history of progressively worsening dyspnea on moderate exertion and orthopnea. Echocardiography revealed right atrial and right ventricle dilation, right ventricle hypertrophy, atrial septal defect, and aneurysmal dilation of the pulmonary artery trunk. This case underscores the importance of early detection and comprehensive imaging in patients suspected of having LDS, particularly considering the potential for atypical vascular manifestations.<\/jats:p>","DOI":"10.1111\/echo.15851","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T14:04:55Z","timestamp":1717596295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed diagnosis of Loeys\u2010Dietz syndrome revealed through atrial septal defect with pulmonary artery dilation"],"prefix":"10.1111","volume":"41","author":[{"given":"Karina Del Valle","family":"Zamora","sequence":"first","affiliation":[{"name":"Clinical Cardiology Department National Institute of Cardiology Ignacio Chavez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda","family":"Fernandez\u2010Sandoval","sequence":"additional","affiliation":[{"name":"Clinical Cardiology Department National Institute of Cardiology Ignacio Chavez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor Alejandro","family":"Quiroz\u2010Martinez\u2010Martinez","sequence":"additional","affiliation":[{"name":"Clinical Cardiology Department National Institute of Cardiology Ignacio Chavez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacobo Sebastian","family":"Vera\u2010Chavez","sequence":"additional","affiliation":[{"name":"Clinical Cardiology Department National Institute of Cardiology Ignacio Chavez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Martinez\u2010Dominguez","sequence":"additional","affiliation":[{"name":"Nuclear Cardiology Department National Institute of Cardiology Ignacio Chavez  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4820-1325","authenticated-orcid":false,"given":"Nilda","family":"Espinola\u2010Zavaleta","sequence":"additional","affiliation":[{"name":"Nuclear Cardiology Department National Institute of Cardiology Ignacio Chavez  Mexico City Mexico"},{"name":"Echocardiography Department ABC Medical Center  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.05.065"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072509"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33263"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.15851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T16:21:57Z","timestamp":1737130917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.15851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":3,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/echo.15851"],"URL":"https:\/\/doi.org\/10.1111\/echo.15851","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"type":"print","value":"0742-2822"},{"type":"electronic","value":"1540-8175"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15851"}}