{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:32Z","timestamp":1753878452354,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prognosis of hypertrophic cardiomyopathy (HCM) varies from mild disease with a normal life expectancy to heart failure and sudden cardiac death (SCD). The identification of patients who are at high risk for SCD remains challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we evaluated the prognostic value of papillary muscle\u2010free strain in HCM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>Seventy\u2010nine patients with a diagnosis of HCM were included in this study. Patients were divided into low\/intermediate\u2010risk (<jats:italic>n<\/jats:italic>\u00a0=\u00a057) and high\u2010risk (<jats:italic>n<\/jats:italic>\u00a0=\u00a022) groups. Two\u2010dimensional (2\u2010D) echocardiography and strain imaging were performed for each patient. The mean age of the study population was 53.85\u00a0\u00b1\u00a015.88 years; 47 (59.5%) of them were male. During a mean follow\u2010up duration of 74.45\u00a0\u00b1\u00a017.03 months, 12 patients died. A comparison of the low\u2010intermediate and high\u2010SCD risk groups revealed that patients in the high\u2010SCD risk group had greater maximal wall thickness, interventricular septum thickness, posterior wall thickness, and left ventricular mass index (LVMI) and lower (less negative) global longitudinal, anterolateral papillary muscle (ALPM) and posteromedial papillary muscle (PMPM) free strain. Additionally, a history of syncope and ICD implantation were found to be more common in patients with high SCD risk scores. The SCD risk score was positively correlated with the global longitudinal strain, ALPM\u2010free strain, and PMPM\u2010free strain (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.528, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.658, and <jats:italic>r<\/jats:italic>\u00a0=\u00a0.600, respectively; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001 for all). Our results showed that the LVMI, presence of syncope, global longitudinal strain, and ALPM\u2010free strain were predictors of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Decreased papillary muscle\u2010free strain values might have prognostic value in patients with HCM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15882","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T10:53:58Z","timestamp":1720522438000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the prognostic value of papillary muscle\u2010free strain in patients with hypertrophic cardiomyopathy"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-1034","authenticated-orcid":false,"given":"Atilla","family":"Koyuncu","sequence":"first","affiliation":[{"name":"Department of Cardiology Bak\u0131rkoy Dr Sadi Konuk Education and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2456-3206","authenticated-orcid":false,"given":"Cennet","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bak\u0131rkoy Dr Sadi Konuk Education and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ersan","family":"Oflar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bak\u0131rkoy Dr Sadi Konuk Education and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busra","family":"Mavi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bak\u0131rkoy Dr Sadi Konuk Education and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulcelil Sait","family":"Ertugrul","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bak\u0131rkoy Dr Sadi Konuk Education and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutfi","family":"Ocal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kosuyolu Education and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Ozan","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Department of Cardiology Izmir Ataturk Education and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Kahveci","sequence":"additional","affiliation":[{"name":"Department of Cardiology Istinye University Liv Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1161\/01.CIR.92.4.785"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.1016\/j.jacc.2014.05.003"},{"doi-asserted-by":"publisher","key":"e_1_2_7_4_1","DOI":"10.1016\/j.jchf.2018.02.010"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1056\/NEJMoa025050"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1056\/NEJM200006153422403"},{"key":"e_1_2_7_7_1","first-page":"e533","article-title":"2020 AHA\/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy: executive summary: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"142","author":"Ommen 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