{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:29:34Z","timestamp":1753878574050,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Device\u2010related thrombosis (DRT) is a common finding after left atrial appendage closure (LAAC) and is associated with worse outcomes. As women are underrepresented in clinical studies, further understanding of sex differences in DRT patients is warranted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This sub\u2010analysis from the EUROC\u2010DRT\u2010registry compromises 176 patients with diagnosis of DRT after LAAC. Women, who accounted for 34.7% (61\/176) of patients, were older (78.0\u00a0\u00b1\u00a06.7\u00a0vs. 74.9\u00a0\u00b1\u00a09.1 years, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.06) with lower rates of comorbidities. While DRT was detected significantly later in women (173\u00a0\u00b1\u00a0267\u00a0vs. 127\u00a0\u00b1\u00a0192 days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01), anticoagulation therapy was escalated similarly, mainly with initiation of novel oral anticoagulant (NOAC), vitamin K antagonist (VKA) or heparin. DRT resolution was achieved in 67.5% (27\/40) of women and in 75.0% (54\/72) of men (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.40). In the remaining cases, an intensification\/switch of anticoagulation was conducted in 50.% (9\/18) of men and in 41.7% (5\/12) of women. Final resolution was achieved in 72.5% (29\/40) cases in women, and in 81.9% (59\/72) cases in men (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.24). Women were followed\u2010up for a similar time as men (779\u00a0\u00b1\u00a0520\u00a0vs. 908\u00a0\u00b1\u00a0687 days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.51). Kaplan\u2013Meier analysis revealed no difference in mortality rates in women (Hazard Ratio [HR]: 1.73, 95%\u2010Confidence interval [95%\u2010CI]:\u00a0.68\u20134.37, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.25) and no differences in stroke (HR:\u00a0.83, 95%\u2010CI:\u00a0.30\u20132.32, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.72) within 2 years after LAAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Evaluation of risk factors and outcome revealed no differences between men and women, with DRT in women being diagnosed significantly later. Women should be monitored closely to assess for DRT formation\/resolution. Treatment strategies appear to be equally effective.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.15888","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T21:20:32Z","timestamp":1721769632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of gender in patients with device\u2010related thrombosis after left atrial appendage closure \u2013 A sub\u2010analysis from the multicenter EUROC\u2010DRT\u2010registry"],"prefix":"10.1111","volume":"41","author":[{"given":"Jacqueline","family":"Saw","sequence":"first","affiliation":[{"name":"Vancouver General Hospital  Vancouver Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3783-2743","authenticated-orcid":false,"given":"Vivian","family":"Vij","sequence":"additional","affiliation":[{"name":"Heart Center University Hospital Bonn Bonn 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left atrial appendage morphology and gender differences by multi\u2010detector computed tomography in an Egyptian population","volume":"72","author":"Elzeneini M","year":"2020","journal-title":"Egypt Hear 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