{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:09:15Z","timestamp":1773000555452,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760314"],"award-info":[{"award-number":["81760314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gestational diabetes mellitus (GDM) poses a risk for cardiovascular damage during pregnancy. This study focused on evaluating changes in left ventricular myocardial performance in GDM patients using the left ventricular pressure\u2010strain loop (LV\u2010PSL) method and examining risk factors associated with reduced myocardial function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective, randomized study involving 112 pregnant women diagnosed with GDM was conducted from June 2021 to June 2024. Additionally, 84 healthy pregnant women from the same period served as the control group. Utilizing both conventional echocardiography and two\u2010dimensional speckle tracking echocardiography, left ventricular myocardial work metrics were assessed using LV\u2010PSL technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GDM patients demonstrated significantly reduced values for global longitudinal strain (GLS), global work index (GWI), global work efficiency (GWE), and global constructive work (GCW) (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), while conventional ultrasound measures showed no significant difference between GDM and control groups. GWI, GWE, GCW, and GLS had high predictive value for cardiac function changes in GDM patients, with GWE showing the highest predictive value {Area under curve (AUC)\u00a0=\u00a00.866, cutoff value\u00a0=\u00a095.5%, specificity\u00a0=\u00a00.77, sensitivity\u00a0=\u00a00.87}. GWI, GWE, and GCW were negatively correlated with GLS (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.532, \u22120.411, \u22120.425, all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), whereas global wasted work (GWW) showed a positive correlation with GLS (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.325 and\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). These parameters were also correlated with HbA1c levels (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.316, \u22120.256, \u22120.260, all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001 for negative correlations, and\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.172,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05 for positive correlations). Multivariate logistic regression indicated that 1\u2010h OGTT (mmol\/L), 2\u2010h OGTT (mmol\/L), and HbA1c (%) were significant predictors of left ventricular systolic function (GWE) in GDM patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LV\u2010PSL is an effective tool for early detection of left ventricular systolic function impairment in GDM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.15944","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:19:04Z","timestamp":1728555544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quantitative Analysis of Myocardial Work in Gestational Diabetes Mellitus Using Noninvasive Left Ventricular Pressure\u2010Strain Loop Measurement"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-1730","authenticated-orcid":false,"given":"Jiaqi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasonics First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihong","family":"Chang","sequence":"additional","affiliation":[{"name":"Hubei Provinical Clinical Research Center for Accurate Fetus Malformation Diagnosis Department of Ultrasound Xiangyang No. 1 People's Hospital Hubei University of Medicine  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changxiu","family":"Yu","sequence":"additional","affiliation":[{"name":"Hubei Provinical Clinical Research Center for Accurate Fetus Malformation Diagnosis Department of Ultrasound Xiangyang No. 1 People's Hospital Hubei University of Medicine  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Peng","sequence":"additional","affiliation":[{"name":"Hubei Provinical Clinical Research Center for Accurate Fetus Malformation Diagnosis Department of Ultrasound Xiangyang No. 1 People's Hospital Hubei University of Medicine  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Feng","sequence":"additional","affiliation":[{"name":"Hubei Provinical Clinical Research Center for Accurate Fetus Malformation Diagnosis Department of Ultrasound Xiangyang No. 1 People's Hospital Hubei University of Medicine  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Song","sequence":"additional","affiliation":[{"name":"Hubei Provinical Clinical Research Center for Accurate Fetus Malformation Diagnosis Department of Ultrasound Xiangyang No. 1 People's Hospital Hubei University of Medicine  Xiangyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics First Affiliated Hospital of Guangxi Medical University  Nanning 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