{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:33:34Z","timestamp":1773012814758,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020217","name":"Sanjay Gandhi Postgraduate Institute of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020217","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Diagnosing cardiac sarcoidosis (CS) is challenging due to the lack of a sensitive gold standard diagnostic test. Although advanced imaging techniques like cardiac magnetic resonance imaging (MRI) (cardiovascular magnetic resonance [CMR]) and fluorodeoxyglucose positron emission tomography (FDG\u2010PET) CT are promising, they are limited by their availability and cost. Two\u2010dimensional speckle\u2010tracking echocardiography (2D\u2010STE) is emerging as a valuable tool for the early detection of CS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center observational study assessed cardiac involvement and the utility of STE as a screening tool for diagnosing CS among newly diagnosed, histologically confirmed, treatment\u2010na\u00efve patients with systemic sarcoidosis in an Indian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 48 newly diagnosed sarcoidosis patients with a median age of 42.5 years (interquartile range [IQR] 34\u201353.5), of whom 52.1% were female. FDG\u2010PET CT findings suggested cardiac involvement in 21 patients, while CMR findings were positive in 11 patients. All patients had normal 12\u2010lead ECGs and echocardiograms. Twenty\u2010five patients met the HRS 2014 criteria for CS diagnosis. The median (IQR) left ventricular global longitudinal strain (LV GLS) was \u221215.4 (\u221216.2, \u221213.4) in the probable CS group and \u221217.9 (\u221219.4, \u221217.4) in the non\u2010CS group. An LV GLS cutoff of &gt;\u221217.3 showed a sensitivity of 80.00% and a specificity of 82.61% (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001, area under the curve [AUC] = 0.790) for CS diagnosis. A right ventricular global longitudinal strain (RV GLS) cutoff of &gt;\u221221.4 showed a sensitivity of 68.00% and a specificity of 78.26% (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.017, AUC = 0.692). They both have very high negative predictive value (98.7% and 97.9%) and thus useful for ruling out the cardiac involvement than confirming it.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>STE effectively screens for cardiac involvement in sarcoidosis patients, ruling out CS diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.15957","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T08:24:53Z","timestamp":1730708693000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Speckle\u2010Tracking Echocardiography as an Effective Screening Tool for Cardiac Involvement Among Patients With Systemic Sarcoidosis in an Indian Cohort: A Prospective Observational Study"],"prefix":"10.1111","volume":"41","author":[{"given":"Prasanth","family":"Areekkara Poduvattil","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zia","family":"Hashim","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudeep","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Ora","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay","family":"Gambhir","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansi","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajmal","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1707-4554","authenticated-orcid":false,"given":"Alok","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinita","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Pathology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.22"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.114.011522"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw328"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1976.tb47058.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101827.1993.tb01149.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad067"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000001240"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ\u201019\u20100508"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"19","article-title":"The WASOG Sarcoidosis Organ Assessment Instrument: An Update of a Previous Clinical Tool","volume":"31","author":"Judson M. 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