{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:33:51Z","timestamp":1773012831634,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371963"],"award-info":[{"award-number":["82371963"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As right heart catheterization (RHC) is invasive and not always accessible, this study developed a noninvasive model (P\u2010echo) to predict shunt closure feasibility in adult congenital heart disease (ACHD) patients with post\u2010tricuspid valve shunt defects (PTD), specifically isolated ventricular septal defects (VSD) and patent ductus arteriosus (PDA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis of 1474 VSD or PDA patients from 2012 to 2022 was conducted. Echocardiographic parameters were assessed, and key variables identified via LASSO regression. The P\u2010echo model incorporated left to right velocity (LRv), right to left velocity (RLv), tricuspid regurgitation (TR), pulmonary artery diameter (PA), and RV\/LV ratio. Its predictive performance was evaluated using ROC curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The P\u2010echo model demonstrated excellent predictive performance with AUC values of 0.975 (95% CI: 0.965\u20130.984) in the derivation set, 0.963 (95% CI: 0.937\u20130.989) in the validation set, and high accuracy in both PDA (AUC 0.975, 95% CI: 0.965\u20130.984) and VSD (AUC 0.958, 95% CI: 0.936\u20130.980) subsets. In the derivation set, the model categorized patients into low (9.1% closure rate), medium (70.9% closure rate), and high\u2010risk groups (99.7% closure rate) for shunt closure feasibility. Calibration plots confirmed the model's accuracy. Decision curve analysis showed a higher net benefit across a range of threshold probabilities, indicating the clinical usefulness of the model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The P\u2010echo model is a robust and reliable tool for predicting the feasibility of shunt closure in patients with PTD, offering a noninvasive alternative to RHC. This model can guide clinical decision\u2010making and support individualized treatment strategies in ACHD management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70016","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T01:43:40Z","timestamp":1730857420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Noninvasive Prediction Model With Simple Echocardiographic Variables for Shunts Closure Possibility in Patients With Posttricuspid Valve Shunt Defect"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8054-9284","authenticated-orcid":false,"given":"Hezhi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong Province 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Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caojin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwen","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Cardiology Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou Guangdong Province 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