{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:31:03Z","timestamp":1780068663906,"version":"3.54.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Insights into quantitative differences between core laboratory and center\u2010reported echocardiographic assessment of the native and bioprosthetic aortic valve are lacking. We aimed to explore clinically relevant differences between these evaluations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were used from the PERIcardial SurGical AOrtic Valve ReplacemeNt (PERIGON) Pivotal Trial for the Avalus valve. In this trial, patients with an indication for surgical aortic valve replacement (SAVR) due to aortic stenosis or regurgitation (AR) were enrolled. Serial echocardiographic examinations were performed at each center and blindly reanalyzed by an independent echocardiographic core laboratory (ECL). For the bioprosthetic valve analysis, postoperative data throughout the 5\u2010year follow\u2010up were pooled. Differences between the ECL and the centers in continuous parameters were quantified in mean differences and intraclass correlation coefficients (ICCs). Agreement on AR, paravalvular leak (PVL), and prosthesis\u2010patient mismatch (PPM) classification was investigated using Cohen's kappa coefficients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis on the native aortic valve was performed on 1118 echocardiograms. The relative mean difference was largest for the left ventricular outflow tract (LVOT) area, followed by stroke volume and effective orifice area (index), with center\u2010reported values being 11%\u20137% higher. High ICCs of around 0.90 were observed for the parameters peak aortic jet velocity, mean pressure gradient, and the velocity\u2010time integral across the aortic valve. Over 5000 echocardiograms were available for the bioprosthetic valve analysis. Therein, comparable results were observed. The kappa coefficient was 0.59 (95% confidence interval [CI] 0.56, 0.63) for agreement on native AR, 0.28 (95% CI 0.18, 0.37) for PVL, and 0.42 (95% CI 0.40, 0.44) for PPM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is high agreement between the ECL and clinical centers on continuous\u2010wave Doppler\u2010related measurements. In contrast, agreement is low for parameters that involve measurement of the LVOT diameter. These results provide important context for the interpretation of aortic valve performance in studies that lack central ECL evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ClinicalTrials.gov identifier: NCT02088554<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.70047","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T10:16:09Z","timestamp":1733220969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Core Laboratory Versus Center\u2010Reported Echocardiographic Assessment of the Native and Bioprosthetic Aortic Valve"],"prefix":"10.1111","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-4220","authenticated-orcid":false,"given":"Bart J. J.","family":"Velders","sequence":"first","affiliation":[{"name":"Cardiothoracic Surgery Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel D.","family":"Vriesendorp","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Weissman","sequence":"additional","affiliation":[{"name":"Cardiovascular Core Laboratories MedStar Health Research Institute, and Georgetown University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Joseph F.","family":"Sabik","sequence":"additional","affiliation":[{"name":"Surgery University Hospitals Cleveland Medical Center and Case Western Reserve University School of Medicine  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Reardon","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Houston Methodist DeBakey Heart and Vascular Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Dagenais","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Quebec Heart and Lung Institute  Quebec Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Moront","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery ProMedica Toledo Hospital  Toledo Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Peter Munk Cardiac Centre Toronto General Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"G\u00fcnzinger","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery German Heart Center Munich, Technische Universit\u00e4t M\u00fcnchen  Munich Germany"},{"name":"Department of Cardiovascular Surgery German Heart Center Munich, Insure (Institute for Translational Cardiac Surgery) Technische Universit\u00e4t M\u00fcnchen  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter J.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Erasmus Medical Center  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Morris","family":"Brown","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery Piedmont Heart Institute  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf H. H.","family":"Groenwold","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology &amp; Biomedical Data Science Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J. M.","family":"Klautz","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Leiden University Medical Centre  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico M.","family":"Asch","sequence":"additional","affiliation":[{"name":"Cardiovascular Core Laboratories MedStar Health Research Institute, and Georgetown University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.02.009"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew025"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15664"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.05.020"},{"issue":"4","key":"e_1_2_12_7_1","first-page":"263","article-title":"Differences Between Echocardiographic Measurements of Left Ventricular Dimensions and Function by Local Investigators and a Core Laboratory in a 2\u2010Year Follow\u2010Up Study of Patients With an Acute Myocardial Infarction","volume":"3","author":"Hole T.","year":"2002","journal-title":"European Journal of Echocardiography"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euje.2007.02.005"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-015-0043-2"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.06.023"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx066"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezac374"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.07.013"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2011.07.003"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa799"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx303"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.03.020"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp361"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjon.2023.08.022"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.01.007"},{"issue":"4","key":"e_1_2_12_22_1","first-page":"245","article-title":"Is Core Laboratory Essential for Using Echocardiography in Clinical Trials? 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